Angina pectoris, cardiac failure, cardiopulmonary oedema, long-term treatment of healed reflux oesophagitis, moderate to severe reflux oesophagitis, myocardial infarction, oesophageal spasm, postoperative hypertension, prinzmetal's angina.
Tachycardia, bradycardia, collapse, hypotension, flushing, tachycardia, coma, palpitations, metabolic acidosis, headache, cardiovascular collapse, syncope, neurologic deficit, weakness, dizziness, nausea, vomiting, restlessness, palpitation, abdominal pain, vertigo, urinary incontinence.
Glyceryl trinitrate is known to interact with other drugs like alcohol, alprostadil, apomorphine, atropine (Sulphate), ergotamine (Tartrate), heparin (Na) and heparin (Cl), imipramine (HCl), quinagolide (HCl), rauwolfia reserpine, reserpine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
SUBSTITUTESNo substitutes found
Can I take Bmd Max Cap(10s) during pregnancy?
Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.