SALT INFORMATIONCabergoline(0.25 mg)
used to treat hyperprolactinemia (high blood levels of prolactin). It may be used for ablactation (to stop or suppress secretion of breast milk) and to treat conditions associated with hyperprolactinemia such as absence of menstruation (amenorrhea), irregular menstruation (oligomenorrhea), absence of ovulation (anovulation), abnormal milky discharge from breasts (galactorrhea) and infertility problems in men and women. . It may also be used to treat Parkinson's disease (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance).
* Very common: fibrotic and inflammatory disorders affecting heart (damage, scarring and inflammation of cardiac tissue that affects functioning of heart – cardiac valvulopathy, pericarditis and pericardial effusion); headache, dizziness, sensation of spinning and rotation (vertigo); urge to vomit (nausea), indigestion (dyspepsia), inflammation of stomach (gastritis), abdominal pain; weakness (asthenia), unusual tiredness (fatigue) * Common: sleepiness (somnolence); feeling depressed; low blood pressure with change of position (orthostatic hypotension), hot flushes; difficulty in passing stool (constipation), vomiting; pain in breasts * Uncommon: irregular heartbeats that one can feel (palpitations); breathlessness (dyspnea); fluid build up between the lungs and wall of the chest (pleural effusion), damage and scarring of tissues of lungs that affects its functioning (pulmonary fibrosis); nosebleed (epistaxis); allergic reaction; increase in sexual desire (increased libido); numb and cold fingers due to decreased blood flow to fingers (digital vasospasm); fainting; swelling; rash, hair loss (alopecia) * Rare: pain in the upper part of abdomen below the ribs (epigastric pain)
* Concomitant use with drugs that block D2 receptor (phenothiazines, butyrophenones, thioxanthenes, or metoclopramide) might reduce the prolactin-lowering effect of cabergoline * Concomitant use with macrolide antibiotics (eg. erythromycin, azithromycin) increases the blood levels of cabergoline * Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Cabergoline belongs to class of drugs called dopamine receptor agonists (stimulates dopamine D2 receptor). It mimics the action of dopamine (a chemical naturally released in the brain which transmits messages) to stop release of hormone prolactin.
* Always follow the instructions of doctor regarding the dosage and duration * Adult - For hyperprolactinemia: 0.25 to 1 mg twice weekly (eg. Monday and Thursday) and increased gradually depending on the patient’s prolactin levels (max. 3g per day) - For stopping lactation: 1 mg once daily on the first day after delivery - For suppression of lactation: 0.25 mg twice a day for 2 days * Children: not recommended in children aged below 16 years
DOs and DON'Ts
* Cabergoline may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking cabergoline. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. * Contact your doctor immediately if you notice any unusual behavior such as addictive gambling, too much eating or spending, abnormally high sex drive or increase in sexual thoughts. * Do consult your doctor before taking cabergoline if you are pregnant or planning to become pregnant. * Do consult your doctor before taking cabergoline if you are breast-feeding * Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects. * Regular monitoring of heart function (tests like ECG) may be advised while on treatment with cabergoline. * Contact your doctor immediately if you notice symptoms like- breathlessness (dyspnea), persistent cough or chest pain; obstruction that may cause pain in abdomen or lower abdomen or loin.
* Do not take or use cabergoline if you are allergic to cabergoline or ergot derivatives (e.g. pergolide, bromocriptine, lisuride, ergotamine or ergometrine) or any other ingredient in the medicine. * Do not take cabergoline if you have a history of cardiac valvular diseases or pulmonary, pericardial, or retroperitoneal fibrotic disorders. * Do not take cabergoline if you have high blood pressure in pregnancy associated with swelling and protein in the urine (preeclampsia, eclampsia, and post-partum hypertension). * Do not take cabergoline if you have blood pressure that cannot be managed by medications (uncontrolled hypertension). * If you are being treated with medications for any mental illness or have a history of mental illness associated with child-birth (puerperal psychosis).
Q..Is cabergoline safe during pregnancy?Studies of cabergoline in pregnant animals do not indicate risk. There are no adequate studies in pregnant women. Cabergoline should be used during pregnancy only if clearly needed. Please follow the advice of your doctor regarding its use.Q.Is cabergoline safe?Yes. Cabergoline is safe if used at prescribed doses for the prescribed duration as advised by your doctor.Q..Is cabergoline a steroid/monoamine oxidase inhibitor (MAOI)?No. Cabergoline stimulates dopamine (D2) receptor and used to lower high levels of prolactin in the body. It does not have a structure or effect similar to steroids. Cabergoline has no known inhibitory activity on enzymes monoamine oxidases (MAO). Q..Is cabergoline a fertility drug? Can I take clomid and cabergoline for fertility?Cabergoline can be used to improve fertility in cases where there are high levels of prolactin. It suppresses high prolactin levels in men and women. Clomid is a brand name for active drug clomiphene that stimulates ovulation (release of egg in women) and improves fertility. Please consult your doctor regarding use of clomid and cabergoline for improving fertility.Q.When is cabergoline used? What is cabergoline used for?Cabergoline is used when there is excess release of hormone prolactin in the body (hyperprolactinemia). It stops release of prolactin and lowers its levels in the blood and used to treat conditions associated with hyperprolactinemia such as absence of menstruation (amenorrhea), irregular menstruation (oligomenorrhea), absence of ovulation (anovulation), abnormal milky discharge from breasts (galactorrhea) and fertility problems in men and women.Q.What is caberlin 0.5?Caberlin is a trade name for active drug cabergoline. Caberlin 0.5 contains 0.5 mg of cabergoline.7.Is cabergoline illegal?No. Cabergoline is not illegal; it belongs to a class of prescription drugs.8.Can I take ibuprofen/paracetamol/Benadryl with cabergoline?Cabergoline has no known serious interaction with ibuprofen, paracetamol or active drugs in Benadryl. Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.Q.Does cabergoline affect your periods/cause hair loss/headaches/constipation/increased libido?Yes. Some possible side effects of cabergoline include – hair loss, changes in menstrual cycle, headache, constipation and increased sexual desire.Q..Does cabergoline cause weight loss?No. Weight loss is not a known side effect of cabergoline.Q.Does cabergoline raise testosterone/ increase dopamine?No. Cabergoline has no known effect on stimulating testosterone release. Cabergoline does not increase release of dopamine. It only mimics the action dopamine by stimulating dopamine (D2) receptors.Q.Does cabergoline shrink pituitary tumors/ is cabergoline a chemo drug?No. Cabergoline has no known direct effect on pituitary tumors. It is not a chemo drug.Q..Does cabergoline work?Yes. Cabergoline is effective in lowering high levels of hormone prolactin in blood (hyperprolactinemia) and treat disorders related to hyperprolactinemia. It is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
* Prescribing information. http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020664s011lbl.pdf * Summary of product characteristics. http://www.medicines.org.uk/emc/medicine/10003 * Patient information leaflet, http://www.medicines.org.uk/emc/PIL.9935.latest.pdf * http://www.nlm.nih.gov/medlineplus/druginfo/meds/a612020.html * http://www.drugs.com/mtm/cabergoline.html
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Can I take Cabgolin (0.25mg) during pregnancy?
Studies in animals have shown no risk to the fetus, however there are no sufficient studies in humans. Patients should follow the advice of the doctor regarding its use. Patients should follow the advice of the doctor regarding its use.