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Composition

Ramipril(5 mg)

SALT INFORMATION

Ramipril(5 mg)

TYPICAL USAGE

Ramipril is mainly used to control high blood pressure (hypertension). It is used to treat heart failure, to improve survival after heart attack and to prevent stroke. Ramipril is also used to treat various kidney diseases.

SIDE EFFECTS

* Common: Headaches, dizziness, decrease in blood pressure (hypotension), blood potassium, excessive fall in blood pressure with change of position (orthostatic hypotension), fainting (syncope), chest pain, non-productive cough, inflammation of air passages (bronchitis), inflammation of the air-cavities (sinuses) around nose (sinusitis), breathlessness (dyspnea), inflammation of the gastrointestinal tract, abdominal discomfort, disturbances in digestion, indigestion (dyspepsia), loose motions (diarrhea), urge to vomit (nausea), vomiting, rashes, muscle cramp/ sudden, involuntary contraction of muscle or group of muscles (muscle spasm), muscle pain (myalgia), unusual tiredness,  insufficient blood supply to the muscles of the heart causing a sensation of pressure, squeezing, or pain in chest (angina pectoris), abnormal blood counts,  

DRUG INTERACTION

* Ramipril should not be coadministered with aliskiren to diabetic patients as it increases the risk of hypotension (low blood pressure), fainting (syncope), stroke, high blood potassium levels (hyperkalemia) and deterioration of kidney function, including kidney failure. * Ramipril should not be coadministered with angiotensin II receptor antagonists (ARBs) in patients with diabetic nephropathy (damage to the kidneys caused by diabetes). * Coadministration of ramipril with potassium salts such as heparin, potassium-retaining diuretics and other plasma potassium increasing active substances (including Angiotensin II antagonists, trimethoprim, tacrolimus, ciclosporin) may lead to hyperkalemia (increased potassium levels in the blood) * Coadministration with other antihypertensive agents (e.g. diuretics), other substances that may decrease blood pressure (e.g. nitrates, tricyclic antidepressants, acute alcohol intake, baclofen, neuoroleptics, alfuzosin, doxazosin, prazosin, tamulsosin, terazosin) can cause hypotension. * Drugs such isoproterenol, dobutamine, dopamine, and epinephrine as well as pain-relieving medications may reduce the hypertensive effects of ramipril when coadministered. * Coadministration of ramipril with allopurinol, immunosuppressants, corticosteroids, procainamide, cytostatics may change blood counts. * Coadministration of ramipril with lithium salts may lead to reduced lithium excretion resulting in lithium toxicity. * Ramipril when coadministered with antidiabetic agents may lead to increased reduction in blood sugar (hypoglycemia)

MECHANISM OF ACTION

Ramipril belongs to a class of drugs called ACE inhibitors (angiotensin converting enzyme inhibitors), Ramipril inhibits the chemical ACE (angiotensin converting enzyme). As a result, there is relaxation of blood vessels leading to a fall in blood pressure which makes it easier for the heart to pump blood.

DOSAGE

Always follow the instructions of doctor regarding the dosage and duration of use * Adults: Oral: 2.5 mg once a day, initially. Dose adjusted as per patient response and maintained up to maximum 10 mg per day once daily or in 2 divided doses. * Elderly: 1.25 mg once a day as initial dose, subsequent doses as decided by your doctor.

DOs and DON'Ts

* Do not take ramipril with any other product containing aliskiren if you are diabetic or have kidney problems. * Do not take ramipril if you have narrowing of one or both arteries that carry blood to kidneys causing reduced blood flow to the kidneys (bilateral renal artery stenosis or renal artery stenosis in a single functioning kidney), abnormally low or unstable blood pressure. * Do not consume if you are undergoing dialysis or any blood filtration technique as ramipril may cause sudden and severe reactions.  * Discontinue ramipril and consult your doctor if you suffer from cough or swelling of eyes and lips (angioedema) * Before taking ramipril, consult your doctor if you are suffering from severe increase in blood pressure, have worsening of symptoms of pre-existing heart failure (decompensated heart failure)

CONTRA INDICATIONS

* Patients with known hypersensitivity to ramipril or to any other ACE inhibitor. * Patients with abnormally low or unstable blood pressure or history of swelling of eyes and lips (angioedema). * Patients suffering from narrowing of vessel that carries blood to kidney bilateral renal artery stenosis or renal artery stenosis  * Women in their second and third trimester of pregnancy or if they are breast feeding

FAQ

Q. Is ramipril a diuretic?No, ramipril is not a diuretic It belongs to a class of drugs called ACE inhibitors (angiotensin converting enzyme inhibitors), mainly used to reduce high blood pressure.Q. Is ramipril safeRamipril is safe if used at prescribed doses for the prescribed duration as advised by your doctor.Q. Is ramipril or cardace a calcium channel blocker/alpha blocker/ beta blocker?No, ramipril or cardace is an ACE inhibitor and shows no known effects on calcium channels or alpha receptors or beta receptors.Q. Is ramipril a nitrate or a statin?Ramipril is neither a nitrate nor a statin. It is an ACE inhibitor used to treat high blood pressure.Q. What are Cardace / Ramistar/Hopace used for?Cardace, Ramistar, Hopace are all trade names for the active drug ramipril. Ramipril is an ACE inhibitor used to treat high blood pressureQ. Can I take ramipril with simvastatin/amlodipine/Viagra/naproxen/prednisolone/ metformin/Sudafed (pseudoephedrine-decongestant preparation)?There are no known serious drug interactions between ramipril when taken with simvastatin/ amlodipine/Viagra/naproxen/prednisolone/metformin/Sudafed. However, consult your doctor about all medications currently taken before starting and while on ramipril.Q. Can I take ramipril with ibuprofen?Ibuprofen can be taken with ramipril, however, it is known that ibuprofen and other NSAIDs may reduce the antihypertensive effects of ramipril. Consult your doctor about any medications currently taken before starting and while on ramipril.Q. Can I take ramipril with food or orange juice?Ramipril can be taken before, with or after food or juice, because food intake does not modify its effects.Q. Does ramipril cause coughing?Yes, non-productive tickling cough, is one of the common side effects or ramipril Q. Does ramipril cause frequent urination?No, ramipril has no known effect on increasing the frequency of urination. It may rarely increase the urine output but not affect the frequency of urination.Q. Does ramipril cause itching?Yes, ramipril may cause itching of skin. It is not very commonly observed.Q. Does ramipril cause an increase in potassium levels in the blood?Yes, increased potassium levels is one a common side effects of ramipril.Q. Does ramipril cause depression?Yes, ramipril may cause depression; however, it is not very commonly observed.Q. Does ramipril thin the blood?No. ramipril has no known effect on blood thinning.Q. Is ramipril available in India?Yes, ramipril is available in India with more than 100 brand names.

FURTHER INFORMATION

* Prescribing/labelling information: http://labeling.pfizer.com/ShowLabeling.aspx?id=716#section-1.3 * Summary of product characteristics: https://www.medicines.org.uk/emc/medicine/24132 * National formulary of India, 4th edition, 2011 * Patient information leaflet: https://www.medicines.org.uk/emc/PIL.26024.latest.pdf

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INTERACTIONS

Can I take Cardiopril (5mg) during pregnancy?

Experiences of drug use and evidence from studies in pregnant women have shown risk to fetus. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Cardiopril (5mg) while breastfeeding/lactation?

Possibly unsafe: Evidence from studies in breastfeeding women show that there is a definite risk of side effects to the breastfed infants. However, use of the drug in breastfeeding women is acceptable in spite of the risk to the infants, if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective. Patients should follow the advice of the doctor regarding its use.

Can I take Cardiopril (5mg) with alcohol?

No studies found