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Composition

Ceftriaxone(250 mg)

SALT INFORMATION

Ceftriaxone(250 mg)

TYPICAL USAGE

Ceftriaxone is used to treat bacterial infections of the brain respiratory tract ear abdomen abdominal wall, urinary tract and kidney, bones, joints, and skin or soft tissues. It is also used in the management of fever with low white blood cells (neutropenia), surgical site infections, joint pain caused by parasite ticks (Lyme disease), typhoid, paratyphoid and sexually transmitted infections (gonorrhea, syphilis).

SIDE EFFECTS

* Common: Diarrhea, rashes, increased liver enzyme, reduced level of blood cells called eosinophils (eosinophilia), low white blood cell count (leucopenia), and reduced level of blood platelets (thrombocytopenia). * Uncommon: Urge to vomit (nausea), vomiting, dizziness, headache, fever, itching of skin (pruritus), inflammation of a vein (phlebitis), injection site pain, increased level of creatinine in blood, reduced level of white blood cells called granulocytes (granulocytopenia), anemia, bleeding disorder (coagulopathy), and genital fungal infection. * Rare: Red blood cells in the urine (hematuria), glucose into the urine (glycosuria).

DRUG INTERACTION

* Ceftriaxone may show drug interaction with oral anticoagulants (warfarin) and increase the risk of bleeding. * It interacts with calcium-containing diluents (Ringer’s solution or Hartmann's solution), or intravenous solutions including continuous calcium-containing infusions such as parenteral nutrition and causes precipitation of the solution. * It may interact with aminoglycoside antibiotics, chloramphenicol and cause kidney toxicity. * It may cause false positive results for urine glucose, galactosemia and Coomb’s test. * Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Ceftriaxone belongs to group of medicines called cephalosporin antibiotics. It kills the bacteria by interrupting the bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptured, thereby killing the bacteria.

DOSAGE

Always follow the instructions of doctor regarding the dosage and duration.For treatment of pneumonia, obstructive pulmonary disease, abdominal and urinary tract infections:Adults and children over 12 years of age:  * 1?2 gm (up to 4 gm) once dailyChildren (15 days – 12 years)(< 50 kg children):  * 50?80 mg (up to 100 mg) for each kg of the child’s body weight once dailyInfants (0-14 days):  * 20-50 mg for each kg of the child’s body weight once dailyNote: Doses are given in powder for solution for intravenous infusion or injection

DOs and DON'Ts

* It is given as a drip (intravenous infusion) or as an injection directly into a vein or into a muscle. It is made up by the doctor, or nurse using water for injections or a suitable infusion fluid. * Do not drive because you may feel sleepy or dizzy while being treated with ceftriaxone. * Tell your doctor if you are taking, have recently taken or might take any other medicines. This includes medicines you can obtain without a prescription.  * Do not start or continue the ceftriaxone and consult your doctor if you have a liver or   kidney disease * Do not take this drug and consult your doctor  if you are pregnant or planning to become pregnant or breastfeeding.

CONTRA INDICATIONS

* Do not take ceftriaxone if you are allergic to any cephalosporin or beta-lactam antibiotics (penicillin, monobactams and carbapenems), or to any ingredients of this drug. * Ceftriaxone should not be given to premature infants aged up to 41 weeks (including gestational age). * It should not be given to full-term infants up to 28 days of age if they require (or are expected to require) calcium treatment or if they have abnormally high level of bilirubin (hyperbilirubinaemia) or low level of bilirubin (hypoalbuminaemia) in blood; jaundice, or increase level of acid in body fluids (acidosis).

FAQ

Q. Is ceftriaxone a form of penicillin drug? Is it bactericidal or bacteristatic?No, ceftriaxone is not a penicillin drug. It is a cephalosporin antibiotic. It is bactericidal drug.Q. Is ceftriaxone safe in liver disease?Yes, ceftriaxone is safe in liver disease. Please consult your doctor for your medical condition before taking the drug.Q. Is ceftriaxone compatible with potassium or potassium chloride?Yes, ceftriaxone is compatible with potassium or potassium chloride when taken together.Q. Is ceftriaxone the same as cephalexin, Monocef-o, Monocef 200, Monocef tablet, Cefakind, or Cefakind 250?No, all are different cephalosporin antibiotics. Monocef-o, Monocef 200, or Monocef tablet contain cefpodoxmine, and Cefakind, or Cefakind 250 contain cefuroxime.Q. What organisms does ceftriaxone cover?Ceftriaxone is active against pseudomonas, staphylococcus, and klebsiella bacteria. It has no activity against chlamydia, methicillin-resistant Staphylococcus aureus (mrsa), and mycoplasma.Q. Is ceftriaxone, or Monocef safe during pregnancy or breastfeeding?Ceftriaxone, or Monocef should only be given during pregnancy or breastfeeding when need has been clearly established. Please consult your doctor before taking the drug.

FURTHER INFORMATION

1. Summary of product characteristics: https://www.medicines.org.uk/emc/medicine/17292. Patient information leaflet: https://www.medicines.org.uk/emc/PIL.7916.latest.pdf3. Prescribing information:     http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/065168s019lbl.pdf

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INTERACTIONS

Can I take Ceftron (250mg) during pregnancy?

Studies in animals have shown no risk to the fetus, however there are no sufficient studies in humans. Patients should follow the advice of the doctor regarding its use. Patients should follow the advice of the doctor regarding its use.

Can I take Ceftron (250mg) while breastfeeding/lactation?

Safer: Drug has been studied in few breastfeeding women and the evidence shows that there is no increase in side effects in the infants, or the possibility of harm to the breastfed infants is expected to be rare. Patients should follow the advice of the doctor regarding its use.

Can I take Ceftron (250mg) with alcohol?

No studies found