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1

SALT INFORMATION

Cetirizine(5mg)

TYPICAL USAGE

Cetirizine is an antiallergic used to treat cold or allergy symptoms such as  sneezing, itching, watery eyes or running nose and skin allergies.

SIDE EFFECTS

* Common: Headache, dizziness, drowsiness, tiredness, restlessness, dry mouth, sore throat, stomach upset, loose motions (diarrhea), urge to vomit (nausea). * Uncommon: Agitation, weakness, feeling of discomfort (malaise), itching, rash, pain in abdomen * Rare: Aggression, depression, weight gain, swelling, movement disorders including muscle spasm, unable to sleep (insomnia), hives, taste disorder, blurred vision, eye movement disorder, difficult, painful or involuntary urination, uncontrolled shaking (tremors), tics.

DRUG INTERACTION

No interactions of cetirizine are expected with other drugs.

MECHANISM OF ACTION

Cetirizine belongs to the group of medicines called antihistamines. It acts by blocking a natural substance (histamine) that is produced in the body during an allergic reaction.

DOSAGE

Always follow the instructions of doctor regarding the dosage and duration Treatment of allergy: * Adults and children (>12 years): 10 mg once daily. * Children (6 to 12 years): 10 mg daily in 2 divided doses.

DOs and DON'Ts

* Do not drive or operate machinery after taking cetirizine because you may feel sleepy. * Avoid alcohol intake while taking this drug. * Consult your doctor if you experience any of these side effects: changes in vision, severe dry mouth, trouble urinating, constipation or drowsiness. * Do not start or continue the cetirizine tablets: * If you are allergic (hypersensitive) to cetirizine or any of the other ingredients of cetirizine tablet. * If you have severe kidney problem or severe liver problem. * If you are pregnant or breast feeding. * Doctor’s advice should be considered before taking cetirizine tablets in case of any following disease conditions such as fits, severe kidney impairment, intolerance to sugars.

CONTRA INDICATIONS

* Children below 6 years. * Patients who have severe kidney problem. * Patients who are allergic (hypersensitive) to cetirizine or any of the other ingredients of cetirizine tablet.

FAQ

Q. Is cetirizine/ Alerid safe?Cetirizine/ Alerid is safe at the prescribed dose by the doctor. Patients should follow the advice of the doctor regarding its use.Q. Is cetirizine/ Alerid/ Alerid syrup an antihistamine/antibiotic/steroid?Cetirizine is an antihistaminic drug. It is not an antibiotic or steroid.Q. Is cetirizine good for cold/ used for sore throat/ allergic reaction/itching/hives?Cetirizine is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose. It is also used to treat hives, but not used for sore throat. Patients should follow the advice of the doctor regarding its use.Q. Is cetirizine/ Alerid D banned?It is available in India and should be taken as advised by doctor.Q. How long can I take cetirizine for?Patient should take cetirizine as directed by doctor.Q. Can you take cetirizine for prickly heat?Cetirizine can be used for prickly heat to reduce the itching. Patients should follow the advice of the doctor regarding its use.Q. Can I take cetirizine with paracetamol/ aspirin/ ibuprofen/ DayQuil/ prednisone/ Benadryl?Cetirizine can be taken along with paracetamol, aspirin, ibuprofen, or prednisone. However, taking Benadryl and Dayquil along with cetirizine can increase the drowsiness. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required.Q. Can I take cetirizine with high blood pressure?Patients with high blood pressure can take cetirizine. Patients should follow the advice of the doctor regarding its use.Q. Can I take cetirizine with loratadine/ diphenhydramine/ brompheniramine/ fexofenadine?No. Patient should not take cetirizine with these drugs as they are from same category of antihistamines. Patients should follow the advice of the doctor regarding its use.Q. Can I take cetirizine with antibiotics/ azithromycin/ citalopram/ sertraline?Yes, as there are no expected reactions with cetirizine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required.Q. Can I take cetirizine with alcohol?Alcohol consumption should be avoided when taking the cetirizine.Q. Does cetirizine make you sleepy or cause drowsiness?Patient may feel sleepy after taking cetirizine. Always consult your doctor.Q. Does cetirizine make you gain weight?It is rarely seen, but there is a possibility that cetirizine, like other anti-histamines might cause gain in weight.Q. Does cetirizine contain diphenhydramine/pseudoephedrine/aspirin/acetaminophen (paracetamol)? No. Cetirizine does not contain diphenhydramine/pseudoephedrine/aspirin. However doctor may prescribe cetirizine in combination with these drugs.

FURTHER INFORMATION

1. US prescribing information. 2. Summary of product characteristics.     http://www.medicines.org.uk/emc/medicine/287313. Prescribing information leaflet.     http://www.medicines.org.uk/emc/PIL.28728.latest.pdf

Pseudoephedrine(120mg)

TYPICAL USAGE

Pseudoephedrine is used for the relief of nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure.

SIDE EFFECTS

* Uncommon: dry mouth, anxiety, restlessness, uncontrolled shaking (tremor), unable to sleep (insomnia), increased heart rate (tachycardia), cardiac arrhythmias, thumping, pounding or fluttering sensation in chest; irregular heartbeats that one can feel (palpitations), high blood pressure (hypertension), urge to vomit (nausea), vomiting, headache and occasionally urinary retention in males and skin rashes. * Rare: seeing or hearing things that are not really there (hallucinations).

DRUG INTERACTION

* Pseudoephedrine should not be given to patients being treated with monoamine oxidase inhibitors or within 14 days of stopping such treatment.  * Taking pseudoephedrine with tricyclic antidepressants, other sympathomimetic agents (such as decongestants, appetite suppressants and amphetamine-like psychostimulants) or with monoamine oxidase inhibitors (including furazolidone), which interfere with the catabolism of sympathomimetic amines and may cause a rise in blood pressure. * The effects of anticholinergics e.g., some psychotropic drugs and atropine, may be potentiated by this product, giving increased tachycardia, mouth dryness, gastrointestinal disturbances. * It may increase the vasoconstrictor effects of ergot alkaloids.  * Concurrent use with halogenated anesthetic agents such as chloroform, cyclopropane, halothane, enflurane or isoflurane may provoke or worsen ventricular arrhythmias.  * The effect of antihypertensive agents which interfere with sympathetic activity may be partially reversed by the pseudoephedrine eg., bretylium, bethanidine, guanethidine, reserpine, debrisoquine, methyldopa, alpha- and beta-adrenergic blocking agents.  * Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Pseudoephedrine belongs to the class of medications called sympathomimetics.. It works by causing narrowing of the blood vessels and reduces swelling in the nasal passages thereby making breathing easier.

DOSAGE

Always follow the instructions of doctor regarding dosage and duration:Treatment of nasal and sinus congestion: * Adults and children (>12 years): 60 mg tablet up to four times daily. 

DOs and DON'Ts

Avoid taking the medicine too close to bedtime as it may keep you awake.Do not use continuously or more than the recommended duration as it can cause rebound congestion.Do not start or continue the pseudoephedrine and consult your doctor: * If you are allergic (hypersensitive) to pseudoephedrine or any of the other ingredients of pseudoephedrine. * If you are hypertensive or diabetic patient. * If you have latent or clinically recognized open angle glaucoma. * If you heart diseases. * If you have prostatic hypertrophy. * If you have hyperthyroidism. * If you have urinary retention.

CONTRA INDICATIONS

* Patients who are allergic (hypersensitive) to pseudoephedrine or any of the other ingredients of pseudoephedrine tablet. * Patients receiving or having received MAO inhibitors * Patients with cardiovascular disease, hypertension, severe kidney impairment, diabetes mellitus, closed angle glaucoma, hyperthyroidism, prostatic enlargement and pheochromocytoma.

FAQ

Q. Is pseudoephedrine banned in India?No. it is available in India as various brands in combinations (eg. Actified, Allegra D).Q. Is pseudoephedrine a blood thinner/diuretic/anticholinergic/NSAID/narcotic/ antihistamine?Pseudoephedrine is a sympathomimetic drug. It is not a diuretic, anticholinergic, NSAID, narcotic or antihistamineQ. Is pseudoephedrine the same as phenylephrine?No, pseudoephedrine is different drug than phenylephrine but both are nasal decongestant.Q. Is pseudoephedrine used in methamphetamine?Pseudoephedrine is used in the illicit manufacture of methamphetamine.Q. Is pseudoephedrine safe/ safe to take every day/ how long can I take pseudoephedrine?It is safe if used at prescribed doses for the prescribed duration as advised by your doctor.Q. Is pseudoephedrine a controlled substance/ addictive?Yes, it is controlled substance and it may be addictive. Pseudoephedrine can be habit-forming and should only be used when prescribed. Doctors will inform the patient to only take the medication as needed.Q. Is pseudoephedrine over the counter/prescription?It is an over the counter medication. Patients should follow the advice of the doctor regarding its use.Q. Is pseudoephedrine safe to take while pregnant?No, it is not safe to take this drug during pregnancy. Always consult your doctor regarding its use.Q. Is pseudoephedrine gluten free?Yes, it is gluten free. However, please refer to package insert of the prescribed brand before use.Q. Can you take pseudoephedrine for allergies?Pseudoephedrine is used for treatment of nasal and sinus congestion. Always consult your doctor regarding its use.Q. How much pseudoephedrine can I take for a cold?Yes. It can be taken for cold. You should take pseudoephedrine for prescribed dose and duration as advised by doctor.Q. Can I take pseudoephedrine with Nyquil/ ibuprofen/ Benadryl/ Mucinex/ Mucinex DM/ guaifenesin/ Tylenol/loratadine/hydrocodone?Taking other medicines may alter the effects of pseudoephedrine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required.Q. Can I take pseudoephedrine with high blood pressure?No, patient with high blood pressure should not take this drug. Always consult your doctor regarding its use.Q. Can I take pseudoephedrine with paracetamol/ Tylenol ibuprofen/antibiotics/Lemsip/Benadryl/Clartin/amoxicillin/citalopram/Mucinex/warfarin?Taking other medicines may alter the effects of pseudoephedrine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required.Q. Does pseudoephedrine/ Actified/ Allegra D make you sleepy/awake/tired/get you high/raise blood pressure/constipation/insomnia/dry you out?Pseudoephedrine and its combination causing the above mentioned side effects are rare or uncommon. However, consult your doctor if you experience any of these side effects.Q. Does pseudoephedrine contain acetaminophen?No, it does not contain acetaminophen in it.

FURTHER INFORMATION

* US prescribing information. http://products.sanofi.ca/en/eltor.pdf * Summary of product characteristics. http://www.medicines.org.uk/emc/medicine/8101

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INTERACTIONS

Can I take Cetrizet D during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Cetrizet D while breastfeeding/lactation?

Contraindicated: The drug should not be used by breastfeeding women, as evidences from studies have shown that there is a high risk of causing significant damage to infants.

Can I take Cetrizet D with alcohol?

No studies found