Combihale Ff(250mg)

Inhaler
MRP:Rs. 514 for 1 Packet(s) (250 mdi Inhaler each)
Discounted Price:Rs. 514 (0% OFF)
1

SALT INFORMATION

Fluticasone Propionate(250mcg)

TYPICAL USAGE

Allergic rhinitis, asthma, atopic eczema, contact sensitivity reactions, dermatitis, discoid eczema, discoid lupus erythematosus, eczema, infantile eczema, neurodermatoses, perennial rhinitis, psoriasis, purigo nodularis, seborrheic dermatitis.

SIDE EFFECTS

Glaucoma, cataract, growth retardation, adrenocortical suppression, decrease in bone mineral density, pruritus, dysphonia, allergic contact dermatitis, cough, oral candidiasis, local burning, hyperpigmentation, hypertrichosis, vocal cord myopathy, throat irritation, superficial blood vessels dilatation, superficial blood vessels thinning.

DRUG INTERACTION

Fluticasone propionate is known to interact with other drugs like carbamazepine, cyclosporin A, frusemide or furosemide, phenytoin (Na), primidone, rifampicin, theophylline, warfarin (Na). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Fluticasone propionate binds to the glucocorticoid receptor with high affinity and produces alteration of transcription and protein synthesis, a decreased release of leukocytic acid hydrolases, reduction in fibroblast proliferation, prevention of macrophage accumulation at inflamed sites, reduction of collagen deposition, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability and subsequent edema, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue.

Formoterol Fumarate(6 mcg)

TYPICAL USAGE

Duodenal ulceration, for prophylaxis in pregnancy, prophylaxis of acid aspiration in obstetric patients.

SIDE EFFECTS

Arrhythmias, headache, palpitation, tachycardia, insomnia, tremor, peripheral dilatation.

DRUG INTERACTION

Steroids or diuretics may potentiate a possible hypokalaemic effect of ?-agonists. Increased susceptibility to cardiac arrhythmias in patients treated with digitalis. Concomitant use with quinidine, disopyramide, procainamide, phenothiazines, antihistamines, MAOI or TCAs can prolong the QT-interval and increase the risk of ventricular arrhythmias. L-dopa, L-thyroxine, oxytocin and alcohol can impair cardiac tolerance towards ?2-sympathomimetics.

MECHANISM OF ACTION

Formoterol fumarate relaxes the bronchial smooth muscle by selectively acting on ?2-receptors with minimal effect on heart rate.

SUBSTITUTES

1 Substitutes
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  • Maxiflo (250)
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    Cipla Ltd
    Rs. 413/Inhaler
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    pay 19988% more per Inhaler

INTERACTIONS

Can I take Combihale Ff(250mg) during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Combihale Ff(250mg) while breastfeeding/lactation?

Moderately safe: No studies have been conducted in breastfeeding women, however there is possibility of ill effect to the breastfed infants; or studies conducted in breastfeeding women show minimal non-threatening side effects to the infants. Drugs should be given only if the potential benefit justifies the potential risk to the infant. Patients should follow the advice of the doctor regarding its use.

Can I take Combihale Ff(250mg) with alcohol?

No studies found