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Composition

Theophylline(450 mg)

SALT INFORMATION

Theophylline(450 mg)

TYPICAL USAGE

Acute severe asthma, apnoea of prematurity, asthma, obstructive airway disease, reversible airways obstruction.

SIDE EFFECTS

Seizures, cardiac arrhythmias, neurotoxicity, headache, irritability, nausea, anorexia, anxiety, tremors,insomnia, nervousness.

DRUG INTERACTION

Theophylline is known to interact with other drugs like adenosine, albuterol, alcohol, allopurinol, aminoglutethimide, amiodarone (HCl), amlodipine (Besylate), azithromycin, bambuterol, bisoprolol (Fumarate), cannabis, carbamazepine, carmustine, celiprolol (HCl), chlortetracycline (HCl), cimetidine (HCl), cinoxacin, ciprofloxacin, clarithromycin, clopidogrel, demeclocycline (HCl), diltiazem (HCl), doxapram, enoxacin, ephedrine, erythromycin, fluconazole, fluticasone propionate, fluvoxamine (Maleate), fosphenytoin, gallopamil, halothane, influenza vaccine, interferon alpha, isoproterenol, ketoconazole, lansoprazole, levobunolol (HCl), levofloxacin, lithium, methotrexate, minocycline (HCl), modafinil, moricizine (HCl), nebivolol (HCl), nelfinavir, nevirapine, nicotine, nifedipine, norfloxacin, obidoxime (Cl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells,possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction.

SUBSTITUTES

No substitutes found

INTERACTIONS

Can I take Deriphyllin Od(450mg) during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Deriphyllin Od(450mg) while breastfeeding/lactation?

Moderately safe: No studies have been conducted in breastfeeding women, however there is possibility of ill effect to the breastfed infants; or studies conducted in breastfeeding women show minimal non-threatening side effects to the infants. Drugs should be given only if the potential benefit justifies the potential risk to the infant. Patients should follow the advice of the doctor regarding its use.

Can I take Deriphyllin Od(450mg) with alcohol?

No studies found