SALT INFORMATIONTheophylline(450 mg)
Acute severe asthma, apnoea of prematurity, asthma, obstructive airway disease, reversible airways obstruction.
Seizures, cardiac arrhythmias, neurotoxicity, headache, irritability, nausea, anorexia, anxiety, tremors,insomnia, nervousness.
Theophylline is known to interact with other drugs like adenosine, albuterol, alcohol, allopurinol, aminoglutethimide, amiodarone (HCl), amlodipine (Besylate), azithromycin, bambuterol, bisoprolol (Fumarate), cannabis, carbamazepine, carmustine, celiprolol (HCl), chlortetracycline (HCl), cimetidine (HCl), cinoxacin, ciprofloxacin, clarithromycin, clopidogrel, demeclocycline (HCl), diltiazem (HCl), doxapram, enoxacin, ephedrine, erythromycin, fluconazole, fluticasone propionate, fluvoxamine (Maleate), fosphenytoin, gallopamil, halothane, influenza vaccine, interferon alpha, isoproterenol, ketoconazole, lansoprazole, levobunolol (HCl), levofloxacin, lithium, methotrexate, minocycline (HCl), modafinil, moricizine (HCl), nebivolol (HCl), nelfinavir, nevirapine, nicotine, nifedipine, norfloxacin, obidoxime (Cl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells,possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction.
SUBSTITUTESNo substitutes found
Can I take Deriphyllin Od(450mg) during pregnancy?
Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.