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Composition

Pioglitazone Hydrochloride(30 mg)

SALT INFORMATION

Pioglitazone Hydrochloride(30 mg)

TYPICAL USAGE

It is used in combination with diet and exercise to lower blood glucose in adults with type 2 diabetes mellitus.

SIDE EFFECTS

* Common: Infection of nose, sinuses, pharynx or larynx (upper respiratory tract infection), decreased sensitivity to stimulation (hypoesthesia), visual disturbance, bone fracture, weight gain. * Uncommon: sinusitis, bladder cancer, inability to sleep (insomnia). * Rare: Elevated liver enzyme, impaired liver cell function.

DRUG INTERACTION

* Pioglitazone interacts with strong CYP2C8 inhibitors (e.g., gemfibrozil): it causes an increase in pioglitazone concentrations. It also interacts with CYP2C8 inducers (e.g., rifampin) that result in decrease of pioglitazone concentrations.  * Pioglitazone when used in combination with other antidiabetic drug metformin has the risk low hemoglobin or red blood cell count (anemia), headache, joint pain (arthralgia), blood in urine (hematuria), problem with erection in males (erectile dysfunction) * Pioglitazone when used in combination with other anti-diabetic drugs like sulphonylurea (e.g. glimepiride, glibenclamide, glipizide, gliclazide etc) has the risk of dizziness or gas (flatulence) * Pioglitazone when used in combination with metformin and sulphonylurea has the risk of excessive fall in blood sugar (hypoglycemia), joint pain (arthralgia), increase in levels of certain enzymes in blood (e.g. creatine phosphokinase) * Pioglitazone when used in combination with insulin has the risk of inflammation of air passage between nose and lungs (bronchitis), decreased blood sugar (hypoglycemia), heart failure, breathlessness (dyspnea), joint pain (arthralgia), back pain, swelling (edema) * Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Pioglitazone belongs to class of thiazolidinedione. Pioglitazone decreases insulin resistance in the periphery and in the liver that helps the body make better use of insulin it produces and also decreases the glucose output from the liver.

DOSAGE

Always follow the instructions of doctor regarding the dosage and duration  * Treatment of type 2 diabetes: 15 mg once daily, up to a maximum of 45 mg once daily.

DOs and DON'Ts

* Consult your doctor if you have any mental confusion, persistant abdominal pain, dark uine, yellowing of skin/eyes or easy bruising * Check your blood sugar regularly * Consult your doctor:                     -If you are allergic to pioglitazone or any of the other ingredients of this medicine.                     -If you have heart failure or have had heart failure in the past.                    -If you have liver disease.                    -If you have had a complication of diabetes causing rapid weight loss, nausea or                           vomiting (diabetic ketoacidosis) or a special type of diabetic eye disease with                             swelling of the back of the eye(macular edema).                    -If you have ever had bladder cancer and blood in urine.                    -If you have cysts on your ovaries (polycystic ovary syndrome).

CONTRA INDICATIONS

* Diabetes patient with a history of severe heart failure. * Patients of type 1 diabetes or diabetic ketoacidosis.

FAQ

Q.Does pioglitazone cause hair loss?No, pioglitazone does not cause hair loss. However, if you experience such side effects, consult your doctor.Q.Does pioglitazone cause bladder cancer or any other cancer?In clinical studies, more people who took pioglitazone for more than one year developed bladder cancer as compared to those who did not take pioglitazone. It is recommended to consult your doctor about the risk of taking this medication if you have had bladder cancer in the past or have a history of passing blood in urine. No other cancer type has been linked with use of pioglitazone.Q.Does pioglitazone cause heart failure?Pioglitazone can cause fluid retention, which may worsen or precipitate heart failure.Q.Is pioglitazone safe?Pioglitazone is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

FURTHER INFORMATION

1.Prescribing information. http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021073s043s044lbl.pdf2.Summary of product characteristics. https://www.medicines.org.uk/emc/medicine/42363.Patient information leaflet. http://www.medicines.org.uk/emc/PIL.11530.latest.pdf4.Medline plus drug informationhttp://www.nlm.nih.gov/medlineplus/druginfo/meds/a699016.html

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INTERACTIONS

Can I take Diavista (30mg) during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Diavista (30mg) while breastfeeding/lactation?

Contraindicated: The drug should not be used by breastfeeding women, as evidences from studies have shown that there is a high risk of causing significant damage to infants.

Can I take Diavista (30mg) with alcohol?

No studies found