Cholangitis, Cholecystitis, Cholecytolithiasis, Cystitis, Nephrolithiasis, Papilitis, Smooth muscle spasm, Stone formation, Ureterolithiasis, Urolithiasis, Vesical tenesmus.
Dizziness, Headache, Nausea, Palpitation, Constipation, Insomnia, Hypotension.
Drotaverine is known to interact with other drugs like levodopa. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Drotaverine inhibits phosphodiesterases hydrolysing cAMP, thereby increasing cAMP concentration, decreasing Ca uptake of the cells and changing the distribution of calcium among the cells. It may also have minor allosteric calcium channel blocking properties.
To treat mild to moderate pain during periods(dysmenorrhea), Heavy bleeding during periods (Menorrhagia) due to any cause, fever, inflammation, migraine headache, tooth pain, muscle and joint pain (arthritis), post-operative pain, post child birth pain, and rheumatoid arthritis.
Urge to vomit (nausea), diarrhea, excessive passing of gas, abdominal pain, stomach ulcer, constipation, inflammation of pancreas, swelling, irritation of skin, bleeding in stomach, proteinuria, jaundice, breakdown of blood cells, inflammation of intestine, indigestion, heartburn, dizziness, headache, drowsiness, skin rashes and increased level of liver enzymes.
Mefenamic acid is known to interact with drugs like warfarin, lithium, digoxin, captopril, enalapril, sulfapyridine, probenecid, methotrexate, ciclosporin, prednisone, torasemide and antidiabetic medications. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Mefenamic acid acts by blocking the effect of enzymes called cyclo-oxygenase (COX). By blocking the effect of COX enzymes, prostaglandins (a hormone-like substance) production is reduced resulting in ease of pain and inflammation.
- Drofem(10 Tablet in Strip)FDC LtdRs. 4.92/TabletRs. 49.25pay 20% more per Tablet
- Dotarinmf(10 Tablet in Strip)Elder Pharamaceuticals LtdRs. 5.50/TabletRs. 55pay 34% more per Tablet
- Inorinem(50 Tablet in Packet)Ind Swift Laboratories LtdRs. 4.10/TabletRs. 205same price
- Inrorinem(50 Tablet in Packet)Ind Swift Laboratories LtdRs. 4.10/TabletRs. 205same price
- Drotikind M(10 Tablet in Strip)Mankind PharmaRs. 4.95/TabletRs. 49.50pay 21% more per Tablet
Can I take Drofem during pregnancy?
Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.