SALT INFORMATIONPhenytoin(100 mg)
Convulsions, epilepsy, migraine prophylaxis, myotonia, prophylaxis of epilepsy, status epilepticus, status epilepticus; seizures in neurosurgery, TIC douloureaux, ventricular arrhythmias.
Ataxia, nausea, vomiting, hypotension, drowsiness, nystagmus, coma, hyperglycemia, stupor, blurred vision, skin rashes, elevated alkaline phosphatase, folate deficiency, hypocalcemia.
Phenytoin sodium is known to interact with other drugs like abacavir, abiraterone acetate, aceclofenac, acetazolamide (Na), acyclovir, alcohol, alcuronium (Cl), alfacalcidol, allopurinol, alprazolam, amiodarone (HCl), amitriptyline (HCl), amlodipine (Besylate), amoxapine, amprenavir, artesunate, aspirin, auranofin, azapropazone, bamifylline, beclomethasone (Dipropionate), benorylate, betamethasone, bleomycin, bromazepam, bupropion (HCl), busulphan, caffeine, calcifediol, carbamazepine, chloramphenicol, chlordiazepoxide (HCl), chlorpheniramine (Maleate), chlorpromazine (HCl), chlorpropamide, cholecalciferol, choline magnesium trisalicylate, cimetidine (HCl), ciprofloxacin, clarithromycin, clobazam, clofibrate, clomipramine (HCl), clonazepam, clopidogrel, clozapine, co-trimoxazole, corticotropin, cortisone (Acetate), cyclosporin A. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas.
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Can I take Eptoin (100mg) during pregnancy?
Experiences of drug use and evidence from studies in pregnant women have shown risk to fetus. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.