SALT INFORMATIONEstradiol(0.025 mg)
menopause, treating vulval or vaginal atrophy, prostate cancer
Gynacomastia, uterine bleeding, breast cancer, endometrial carcinoma, headache, depression, weight gain, nausea and vomiting, fluid retention, breast tenderness.
Estradiol. is known to interact with other drugs like phenytoin (Na), rifampicin, sulphamethizole. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
SUBSTITUTESNo substitutes found
Can I take Estraderm Mx(0.025mg) during pregnancy?
The drug should not be used by pregnant women. Experiences of drug use and evidence from studies in pregnant women have shown high risk to fetus. The risk of drug use in pregnant women outweighs the benefit.