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Composition

Fluoxetine(20 mg)

SALT INFORMATION

Fluoxetine(20 mg)

TYPICAL USAGE

Fluoxetine is used in the treatment of depression (including pediatric depression), obsessive-compulsive disorder (in both adult and pediatric population), bulimia nervosa (eating disorder) and panic disorder.

SIDE EFFECTS

Fever, muscle stiffness or tremor, changes in your mental state like confusion, irritability and extreme agitation (serotonin syndrome), Itching of skin (pruritus) , rash, pale, red, raised, itchy, skin (urticaria), inflammation of blood vessel (vasculitis), serum sickness, swelling of eyes and lips (angioedema), loose motion (diarrhea), urge to vomit (nausea), vomiting, indigestion (dyspepsia), difficulty in swallowing (dysphagia), altered taste , dry mouth, abnormal liver function tests, headache, abnormal dreams, lack of sleep (insomnia), dizziness, loss of weight (anorexia),unusual tiredness (fatigue), sleepiness (somnolence), drowsiness, transient abnormal movement, fits (seizures), psychomotor restlessness, seeing or hearing things which are not there (hallucinations), manic reaction, confusion, agitation, anxiety, impaired concentration and thought process, panic attacks, urinary retention, urinary frequency, sexual dysfunction, abnormal milk secretion (galactorrhoea), loss of hair (alopecia), yawn, blurred vision, dilated pupil (mydriasis), sweating, dilation of blood vessel (vasodilatation), muscle, joint or bone pain or stiffness (arthralgia), muscle pain (myalgia), low blood pressure with change of position (postural hypotension), bruise (ecchymosis), gynaecological bleeding, gastrointestinal bleedings, low sodium level (hyponatremia), inflammation of pharynx (pharyngitis), breathlessness (dyspnea), pulmonary inflammation, increased risk of bone fractures. 

DRUG INTERACTION

* Non-selective MAO-inhibitor B (selegilline) and MAO-inhibitors type (moclobemide) lithium, tryptophan increases risk of serotonin syndrome when administered concomitantly with fluoxetine.  * Concomitant administration with clozapine, tramadol and triptans (sumatriptan), there is an increased risk of hypertension.  * Flecainide or encainide, phenytoin, carbamazepine, tricyclic antidepressants (imipramine, desipramine and amitriptyline) may possibly change the blood levels of these medicines.  * Warfarin or other medicines used to thin the blood may alter the effect fluoxetine. * Herbal remedy, St. John's wort may increase side effects of fluoxetine.  * Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Fluoxetine is used in the treatment of depression (including pediatric depression), obsessive-compulsive disorder (in both adult and pediatric population), bulimia nervosa (eating disorder) and panic disorder.

DOSAGE

Always follow the instructions of doctor regarding the dosage and duration.Major depression * Adult: 20 mg once daily; maximum 60 mg once daily. * Elderly: maximum 40 mg once daily but 60 mg can be used. * Child & adolescent (8–18 years): 10 mg once daily, maximum 20 mg once daily..Bulimia nervosa * Adult (over 18 years): 60 mg once daily.Obsessive-compulsive disorder * Adult (over 18 years): 20 mg once daily; maximum 60 mg once daily. * Elderly: maximum 40 mg once daily but 60 mg can also be used.Panic disorder (with or without agoraphobia) * Adult: 10 mg once daily.

DOs and DON'Ts

* Do not start or continue fluoxetine and consult your doctor If  you develop a rash or other allergic reactions (like itching, swollen lips or face or shortness of breath). * Do not suddenly withdraw or discontinue therapy. * The drug can lower sex drive. If the problem persists after the first 2 or 3 months, consult your doctor. * Do not take this drug if you are consuming antidepressants (monoamine oxidase inhibitors) or have been taking them within the previous two weeks. * Avoid drinking alcohol while taking fluoxetine * Fluoxetine can impair mental and physical coordination and, therefore, caution has to be taken before operating an automobile or machinery or engaging in activities requiring mental alertness and coordination.

CONTRA INDICATIONS

Fluoxetine should not be used in patients having allergy to fluoxetine or any of its ingredients. Patients, who are taking monoamine oxidase inhibitors (MAOIs) or have taken within the last 14 days.

FAQ

Q. Is fluoxetine addictive?No, patients should follow the advice of the doctor regarding its use.Q. Is fluoxetine a mono amine oxidase inhibitor?No, fluoxetine belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs).Q. Is fluoxetine a narcotic/controlled substance?No, patients should follow the advice of the doctor regarding its use.Q. Is fluoxetine safe?Fluoxetine is safe, if used at prescribed doses for the prescribed duration as advised by your doctor.Q. Does fluoxetine cause headache/constipation/weight gain/sleepiness/fatigue?Headache is a side effect with the use of fluoxetine however constipation/weight gain/sleepiness/fatigue has not been reported. Patients should consult doctors regarding the possible side effects.Q. Can I take fluoxetine for anxiety?No, it is used for the treatment of major depression, obsessive-compulsive disorder, bulimia nervosa and panic disorder.Q. Is fluoxetine a placebo?No, it is an active drug belonging to a class of medications called selective serotonin reuptake inhibitor (SSRIs) antidepressants.Q. Is fluoxetine a stimulant?No, fluoxetine belongs to a class of medications called selective serotonin reuptake inhibitors (SSRI) antidepressants.Q. Can I take fluoxetine with diazepam/phentermine/alcohol/naproxem/amitriptyline/ paracetamol/Nyquil/tramadol/ibuprofen/ citalopram?With tramadol there is an increased risk of hypertension, amitriptyline may possibly change the blood levels of fluoxetine, and alcohol may alter the effect of fluoxetine. No clinically observed drug interaction has been reported with diazepam, phentermine, naproxen, paracetamol, Nyquil, ibuprofen and citalopram. Please consult your doctor when using concomitantly.Q. How long can I take fluoxetine?It is advisable to take this drug only till prescribed by the doctor.

FURTHER INFORMATION

1. Prescribing information.     http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018936s091lbl.pdf2. Summary of product characteristics. http://www.medicines.org.uk/emc/medicine/299923. Product information leaflet. http://www.medicines.org.uk/emc/PIL.29966.latest.pdf4. Medline plus drug information.     http://www.nlm.nih.gov/medlineplus/druginfo/meds/a689006.html5. British national formulary. 

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INTERACTIONS

Can I take Flutop La(20mg) during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Flutop La(20mg) while breastfeeding/lactation?

Contraindicated: The drug should not be used by breastfeeding women, as evidences from studies have shown that there is a high risk of causing significant damage to infants.

Can I take Flutop La(20mg) with alcohol?

No studies found