Metformin is used in the treatment of diabetes mellitus, insulin resistance, and obesity.
The common side effects are urge to vomit, vomiting, diarrhea, abdominal pain, loss of appetite, malabsorption of vitamin B12, taste disturbance, and altered liver functions. Also, the patient may have the side effects of lactic acidosis (symptoms are vomiting, abdominal pain with muscle cramps, not feeling well with severe tiredness, and difficulty in breathing), and skin reactions such as redness of skin, itching, hives (pale red, raised, itchy bumps of skin).
Taking metformin with other anti-diabetic drugs may lead to excessive lowering of bloodsugar. If you go for an X-ray or scan, do not take metformin before and at least 48 hours afterwards. Metformin with diuretics (furosemide), anti-asthmatic drugs such as salbutamol or terbutaline, or corticosteroids (prednisone) may affect the glucose control. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
The exact mechanism of action of metformin is not clear but it appears to act by decreasing glucose absorption from the intestine, decreasing production of glucose from proteins and fats in liver, and enhancing insulin sensitivity in muscle by increasing glucose uptake and utilization.
Sitagliptin is used to lower blood sugar levels in adult patients with type 2 diabetes mellitus.
Low blood sugar, urge to vomit, vomiting, excessive passage of wind or gas, inflammation of the pancreas (manifests as sever and persistent pain in abdomen, which may reach up to the back, associated with an urge to vomit or frank vomiting). Contact you doctor immediately if serious allergic reaction including rash, hives, swelling of the face, lips, tongue, and throat with difficulty in breathing or swallowing develops.
Sitagliptin in combination with other anti-diabetic drugs may cause excessive lowering of blood sugar. It may interact with other drugs including ketoconazole, ritonavir, clarithromycin, probenecid, and digoxin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Sitagliptin blocks the action of a certain enzyme (dipeptidyl peptidase-4) and prolongs the action of hormones involved in the release of insulin, thereby reducing blood glucose levels.
- Janumet (50/500mg)(30 Tablet in Strip)Merck Sharp & Dohme CorporationRs. 23.20/TabletRs. 696pay 5% more per Tablet
Can I take Istamet (50/50mg) during pregnancy?
The drug should not be used by pregnant women. Experiences of drug use and evidence from studies in pregnant women have shown high risk to fetus. The risk of drug use in pregnant women outweighs the benefit.
Can I take Istamet (50/50mg) while breastfeeding/lactation?
Can I take Istamet (50/50mg) with alcohol?
Since there is some doubt about the results of concurrent use in this interaction, it is advised to give some guidance to the patient about its possible adverse effects and/or consider close monitoring.