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Composition

Calamine(),Ketoconazole(),Zinc Oxide()

SALT INFORMATION

Calamine()

TYPICAL USAGE

Soothing and protective agent. Sunburn, insect bite, urticaria and contact dermatitis.

SIDE EFFECTS

Vomiting, gastritis, rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue.

DRUG INTERACTION

Calamine is known to interact with other drugs like phenoxymethylpenicillin (K). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Calamine has mild astringent and antipruritic actions. Calamine is an anti-itch medication that works by causing a cooling sensation as it evaporates on your skin.

Ketoconazole()

TYPICAL USAGE

Blastomycosis, Candidiasis, Candiduria, Chromomycosis, Chronic mucocutaneous candidiasis, Coccidloidomycosis, Histoplasmosis, Oesophageal candidiasis, orophyaryngeal candidiasis, Paracoccidloidomycosis. Chronic Vag candidiasis.

SIDE EFFECTS

Impotence, papilloedema, androgen suppression, oligospermia, gynecomastia, dizziness, headache, nausea, vomiting, alopecia, diarrhea, abdominal pain, urticaria, pruritus, itching, thrombocytopenia, photophobia.

DRUG INTERACTION

Ketoconazole is known to interact with other drugs like abiraterone acetate, alcohol, alfentanil (HCl), aliskiren, alprazolam, aluminium hydroxide and oxide, amphotericin B, aprepitant, artesunate, astemizole, beclomethasone (Dipropionate), bosentan, carbamazepine, cimetidine (HCl), cisapride, corticotropin, cyclosporin A, dabigatran, desonide, didanosine, docetaxel, eplerenone, erlotinib, famotidine, fexofenadine, flunisolide, indinavir (Sulphate). Always consult your physician for the change of dose regimen or an alternative drug choice that may strictly be required.

MECHANISM OF ACTION

Ketoconazole interacts with 14-? demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol causes inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.

Zinc Oxide()

TYPICAL USAGE

Dandruff, dermatologicals, eczema, skin diseases.

SIDE EFFECTS

Rash, hives, difficulty in breathing and swelling of the mouth, face, lips, or tongue.

DRUG INTERACTION

Zinc Oxide is known to interact with other drugs like heparin (Na) and heparin (Cl), ichthammol, phenoxymethylpenicillin (K), sodium calciumedetate. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Zinc oxide has astringent, soothing and protective properties and is used in topical preparations for eczema, slight excoriations, wounds and haemorrhoids. It also reflects ultraviolet radiation and can be used as a physical sunscreen.

SUBSTITUTES

No substitutes found

INTERACTIONS

Can I take K (2) during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take K (2) while breastfeeding/lactation?

Safer: Drug has been studied in few breastfeeding women and the evidence shows that there is no increase in side effects in the infants, or the possibility of harm to the breastfed infants is expected to be rare. Patients should follow the advice of the doctor regarding its use.

Can I take K (2) with alcohol?

No studies found