Atorvastatin is used to treat patients with elevated cholesterol, triglyceride or lipoprotein levels in blood, and to reduce the risk of heart diseases, even when blood cholesterol is normal.
The common side effects are nose and throat infection, throat pain, nose-bleed, allergic reactions, increase in blood glucose level, gastro-intestinal disturbances like urge to vomit, constipation, indigestion, diarrhea and excessive passage of wind or gas, muscle wasting condition (rhabdomyolysis), elevation of enzymes like blood creatine kinase and liver enzymes.
Atorvastatin is known to interact with other drugs like gemfibrozil (increased risk of rhabdomyolysis), antibiotics and anti-fungal medicines, amprenavir, cimetidine, colestipol, cyclosporin, digoxin, warfarin, and oral contraceptives, where atorvastatin may affect the action of these drugs or vice versa. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Atorvastatin blocks the action of the enzyme (HMG-CoA reductase) that is required for the production of cholesterol in the body. It thus lowers the level of blood lipids such as cholesterol and triglycerides.
To lower the levels of fats (lipids such as cholesterol and triglycerides) in the blood.
Destruction of muscle tissue which may lead to kidney failure (rhabdomyolysis), inflammation of the liver (hepatitis), moderately elevated liver enzymes (liver dysfunction), stomach pain, urge to vomit (nausea), vomiting, diarrhea, rash, itching, gallstones, inflammation of the pancreas, blood clots in the legs causing redness or swelling (deep vein thrombosis), muscle pain, reduced sex drive, and sensitivity to sun light.
Taking Fenofibrate with an anticoagulant (blood thinner such as acenocoumarol, anisindione, and dicumarol) may increase bleeding. Fenofibrate interacts with statins (cerivastatin, lovastatin, pravastatin) and may increase muscular disorder. It is also known to interact with cyclosporine and oesterogen containing contraceptives. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Fenofibrate works by activation of enzyme lipoprotein lipase that increases the breaks down and elimination of fats from blood.
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Can I take Lipicard Av during pregnancy?
The drug should not be used by pregnant women. Experiences of drug use and evidence from studies in pregnant women have shown high risk to fetus. The risk of drug use in pregnant women outweighs the benefit.