MRP:Rs. 22.39 for 1 Strip(s) (10 Tablet each)
Discounted Price:Rs. 22.39 (0% OFF)
1
Report Error

Composition

Isoniazid(50mg),Rifampicin(300 mg)

SALT INFORMATION

Isoniazid(50mg)

TYPICAL USAGE

It is used for all forms of pulmonary and extra-pulmonary tuberculosis.

SIDE EFFECTS

Liver injury, nausea, vomiting, tachycardia, convulsions, coma, seizures, urinary retention, dizziness, hyperreflexia, slurred speech.

DRUG INTERACTION

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

MECHANISM OF ACTION

Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Specifically isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.

Rifampicin(300 mg)

TYPICAL USAGE

Epilepsy (monotherapy), Iron-deficiency anaemia with chronic renal failure, Leprosy, Meningitis, Meningitis prophylaxis, Mycobacterial infection, Paget's disease of bone, Tuberculosis, Urinary tract infection

SIDE EFFECTS

Nausea, Vomiting, Anorexia, Abdominal discomfort, Orange coloration of secretions.

DRUG INTERACTION

Epilepsy (monotherapy), Iron-deficiency anaemia with chronic renal failure, Leprosy, Meningitis, Meningitis prophylaxis, Mycobacterial infection, Paget's disease of bone, Tuberculosis, Urinary tract infection

MECHANISM OF ACTION

Rifampicin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

SUBSTITUTES

No substitutes found

INTERACTIONS

Can I take Macox Zh Kid during pregnancy?

Experiences of drug use and evidence from studies in pregnant women have shown risk to fetus. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Macox Zh Kid while breastfeeding/lactation?

Possibly unsafe: Evidence from studies in breastfeeding women show that there is a definite risk of side effects to the breastfed infants. However, use of the drug in breastfeeding women is acceptable in spite of the risk to the infants, if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective. Patients should follow the advice of the doctor regarding its use.

Can I take Macox Zh Kid with alcohol?

Since there is some doubt about the results of concurrent use in this interaction, it is advised to give some guidance to the patient about its possible adverse effects and/or consider close monitoring.