MRP:Rs. 61 for 1 Strip(s) (10 Tablet each)
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1

SALT INFORMATION

Pregabalin(50 mg)

TYPICAL USAGE

Pregabalin is used to treat seizures, pain caused by damage to the nerves, and generalized anxiety disorders in adults.

SIDE EFFECTS

Common side-effects include headache, sleepiness, dizziness, increased appetite, feeling of elation, confusion, disorientation, decrease in sexual interest , irritability, decreased attention span, memory impairment, abnormal sensations (tingling, numbness), blurred vision, spinning sensation, double vision, difficulty in achieving and maintaining penile erection, vomiting, constipation, dry mouth, excessive passage of wind or gas, weight gain, sore throat, and swelling of the body.

DRUG INTERACTION

Pregabalin when used with medicinal products containing oxycodone, lorazepam and alcohol may increase the side effects like vertigo, sleepiness, decreased concentration. Alcohol consumption should be avoided when taking the drug pregabalin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Pregabalin modifies the release of certain substances released by the nerves in the brain (neurotransmitters) to restrict the transfer of pain signals between nerves, thereby reducing pain caused by damage to the nerves, as well as symptoms of seizures.

Mecobalamin(500 mcg)

TYPICAL USAGE

To treat low hemoglobin or red blood cells (pernicious and megaloblastic anemia), loss of sensation and pain in extremities (neuropathy). Also used as adjunct therapy in rare conditions that involves severe muscle tightness and decrease in muscle mass (amyotrophic lateral sclerosis).

SIDE EFFECTS

It is usually safe when taken orally. Loss of appetite, nausea, vomiting, diarrhea, allergic reactions (skin rashes), itching and other injection site related side effects (pain and blood clots) may occur.

DRUG INTERACTION

Omeprazole, lansoprazole, cimetidine, famotidine, ranitidine, neomycin, colchicine, chloramphenicol reduce blood levels of mecobalamine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Mecobalamin (active form of vitamin B12) assists important enzymes involved in energy production form fats and proteins and synthesis of haemoglobin. It is known to increase production and development of red blood cells by the bone marrow. It assists enzyme methionine synthase which is involved in breakdown of homocysteine thereby reducing its level.

SUBSTITUTES

No substitutes found

INTERACTIONS

Can I take Megabid (50mg) during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Megabid (50mg) while breastfeeding/lactation?

Contraindicated: The drug should not be used by breastfeeding women, as evidences from studies have shown that there is a high risk of causing significant damage to infants.

Can I take Megabid (50mg) with alcohol?

Since there is some doubt about the results of concurrent use in this interaction, it is advised to give some guidance to the patient about its possible adverse effects and/or consider close monitoring.