SALT INFORMATIONIsosorbide Mononitrate(10 mg)
Isosorbide mononitrate is used in adults to prevent angina (chest pain).
* Very Common: headaches (usually at the start of treatment) * Common: feeling dizzy; low blood pressure when standing up (postural hypotension); slow or fast heart beat; flushing; restlessness; looking pale; weakness; tiredness; cold perspiration; dizziness, tiredness, feeling weak * Rare: rash and itching; pain in your muscles or joints; drowsiness; urge to vomit, vomit and diarrhea; sensitivity to light; fainting or collapse; low levels of oxygen in the blood; bleeding in the brain; worsening angina * Very rare side effects: red or scaly skin (exfolilative dermatitis)
Avoid concomitant use with the following and tell your doctor if you are taking: * medicines used to treat high blood pressure (e.g. propranolol, furosemide) * medicines used to treat heart failure (e.g. nifedipine, ramipril) * medicines used in the treatment of erectile dysfunction (e.g. sildenafil, avanafil, tadalafil, vardenafil and riociguat) * any medication which may cause a lowering of your blood pressure (medicines such as noradrenaline, which are used to treat high blood pressure or a heart attack * acetylcholine, which is used during some operations * medicines such histamine, which is used to treat allergic reactions * medicines used to treat migraines (e.g. ergotamine)Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required
MECHANISM OF ACTION
Isosorbide mononitrate belongs to a group of medicines called organic nitrates that works by widening the blood vessels in heart to allow an increased amount of blood to flow to areas which need it.
Always follow the instructions of doctor regarding the dosage and duration. The dosage and duration for the prophylaxis of angina pectoris in adults: One or two tablets (dose range 25 to 120mg) in a day, preferably in the morning.
DOs and DON'Ts
Take isosorbide mononitrate by mouth on an empty stomach with a full glass of water.Do not take isosorbide mononitrate If you are allergic to isosorbide mononitrate or any of the other ingredients Check with your doctor before taking isosorbide mononitrate if you are pregnant, planning to become pregnant, or are breast-feeding * Do not drink alcohol. * Do not drive or operate machinery as the drug can make you dizzy or drowzyIsosorbide mononitrate is not indicated for relief of acute anginal attacks The drug can can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use the medication. Do not stop taking isosorbide mononitrate. Ask your doctor before using any headache pain medication.
* Do not take isosorbide mononitrate if: * If you are allergic to isosorbide mononitrate or any of the other ingredients * If you have been diagnosed with any of the severe heart disease * If you suffer from severe anemia (low levels of red blood cells in the blood) or low volume of blood in your body (hypovolaemia); * If you have a head injury or bleeding of the brain; * If you have closed-angle glaucoma (high pressure in the eyes); * If you have very low blood pressure * If your blood has stopped circulating around your body properly (circulatory failure) or have decreased blood supply to the brain (cerebrovascular insufficiency) * Not recommended for children.
Q. Is isosorbide mononitrate a beta blocker/a blood thinner/a calcium channel blocker/a statin/ace inhibitor/a diuretic/ a narcotic?No, isosorbide mononitrate is vasodilator. It is not a beta blocker, a blood thinner, a calcium channel blocker, ace inhibitor/a diuretic or a statin. It is not a narcotic but narcotic symptoms may develop in some people.Q. Does isosorbide mononitrate cause erectile dysfunction (ed)/lower blood pressure/hair loss?Isosorbide mononitrate does not cause erectile dysfunction but should not be used with the drugs such as Viagra used to treat ED. Low blood pressure is a common side effect of isosorbide mononitrate. Hair loss is not common, but may occur in some especially in older (60+) females.Q. Can isosorbide mononitrate be crushed/cut half/be split?Do not crush, split, cut half or chew the isosorbide mononitrate tablets. Its efficacy may get reduce. Always follow your doctor’s advice regarding its use.Q. Is isosorbide mononitrate the same as isosorbide dinitrate?Isosorbide mononitrate is the active metabolite of isosorbide dinitrate and is primarily used in the management of chronic stable angina. It has high bioavailability and a longer half-life (4-6 hours) than isosorbide dinitrate.Q. Can i take paracetamol with isosorbide mononitrate?No interactions are found for paracetamol with isosorbide mononitrate, but it does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.Q. Can isosorbide mononitrate get you high?No, isosorbide mononitrate does not get you high.Q. Can isosorbide mononitrate be taken at night?It is better to take isosorbide mononitrate in the morning during the time patients are active and leave them drug free during sleep.
1. Summary of product characteristics- https://www.medicines.org.uk/emc/medicine/10798 2. Patient information leaflet- https://www.medicines.org.uk/emc/PIL.27880.latest.pdf3. http://www.drugs.com/isosorbide_mononitrate.html
Can I take Monosorbitrate (10mg) during pregnancy?
Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.