Aspirin is used to treat mild to moderate pain including headache, toothache, sore throat, period pains, symptomatic relief of sprains, strains, joint and connective tissue pain, lower back pain, pain in buttocks, hips, or adjacent parts, fever and feverish colds, muscle pain, joint swelling, stiffness and pain, and reduce fever. At a lower dose, it is used to reduce the likelihood of heart attack in case the patient has had heart attack, anginal pain, heart surgery or stroke.
Severe allergic reaction including skin rash and itching, swelling of eyelids, face, lips, mouth or tongue, breathlessness or worsening of asthma attacks, stomach upset, pain, stomach and intestinal ulcers and bleeding leading to vomiting or black stools, bruising, ringing or buzzing in the ear.
Use of aspirin along with other pain-killers or corticosteroids may increase the likelihood of stomach and intestinal side effects. Aspirin may aggravate the effects of diuretics, phenytoin and valproate. Aspirin administered with anticoagulants such as warfarin may cause increased risk of bleeding. Metoclopramide may slow down the effects of aspirin. Aspirin may delay the removal of methotrexate and thus may cause toxic effects. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Chemicals like prostaglandins are released when there is injury, infection or inflammation and this causes pain and fever. Aspirin decreases the amount of this chemical (prostaglandin) in the body by blocking the enzyme that makes prostaglandins (cyclooxygenase). As a consequence, swelling, pain, and fever are reduced. Inhibition of prostaglandins also reduces the function of platelets and the ability of blood to clot.
To prevent and treat excessive clotting of blood that can cause heart attacks, strokes, or death.
Bleeding in the stomach or intestine, collection of blood outside the blood vessels, skin bruising and collection of blood under the skin or soft tissues, nose bleeding, blood in the urine, diarrhea, abdominal pain, heartburn, indigestion, hepatitis, swelling of the body, dizziness, tiredness, felling sick, rashes, depression, arthralgia, and influenza.
Clopidogrel may interact with other drugs used to reduce blood clotting (warfarin, heparin), pain-killers used to treat painful and/or inflammatory conditions of muscle or joints, omeprazole, esomeprazole or cimetidine, fluconazole, voriconazole, ciprofloxacin, chloramphenicol, fluoxetine, fluvoxamine, moclobemide, carbamazepine, oxcarbazepine, and ticlopidine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Clopidogrel is an antiplatelet drug, which works by blocking platelets from sticking together and prevents them from forming harmful clots. It helps keep blood flowing smoothly in the body.
- Combiplet(10 Capsule in Strip)Sun Pharmaceutical Industries LtdRs. 2.87/CapsuleRs. 28.66save 19% more per Capsule
- Plagril A Caps(10 Capsule in Strip)Dr Reddy's Laboratories LtdRs. 2.95/CapsuleRs. 29.50save 16% more per Capsule
- Synplatt (75)(10 Capsule in Strip)FDC LtdRs. 2.97/CapsuleRs. 29.70save 16% more per Capsule
- Synplatt (150mg)(10 Capsule in Strip)FDC LtdRs. 3.02/CapsuleRs. 30.25save 14% more per Capsule
- Clopact A(75mg)(10 Capsule in Strip)Ipca Laboratories LtdRs. 3.20/CapsuleRs. 32save 9% more per Capsule
Can I take Plagril A(75) during pregnancy?
Experiences of drug use and evidence from studies in pregnant women have shown risk to fetus. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.
Can I take Plagril A(75) while breastfeeding/lactation?
Can I take Plagril A(75) with alcohol?
Since there is some doubt about the results of concurrent use in this interaction, it is advised to give some guidance to the patient about its possible adverse effects and/or consider close monitoring.