Proxyn (300mg)

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Composition

Etodolac(300 mg)

SALT INFORMATION

Etodolac(300 mg)

TYPICAL USAGE

Etodolac is used to relieve painful conditions of the bone, joints and soft tissues such as   inflammatory arthritis (rheumatoid arthritis) and advanced osteoarthritis.

SIDE EFFECTS

Peptic ulcers, perforation or GI bleeding, nausea (urge to vomit), vomiting, diarrhea, flatulence, constipation, dyspepsia (indigestion), abdominal pain, bright red bloody stools (melena), vomiting blood (hematemesis), ulcers in and around the mouth, exacerbation of colitis and Crohn's disease, gastritis (inflammation of the gastrointestinal tract), inflammation of the pancreas (pancreatitis), asthma, aggravated asthma, bronchospasm or breathlessness (dyspnea), itching ok skin (pruritus), severe or non-severe skin reactions, edema, high blood pressure (hypertension) and heart failure (cardiac failure), heart attack (myocardial infarction), stroke, fever, weakness (malaise), visual disturbances, inflammation of the optic nerve (optic neuritis), headaches, abnormal sensations (tingling, numbness, pricking, burning) of skin (paresthesia), depression, confusion, seeing or hearing things that are not really there (hallucinations), ringing in ears (tinnitus), vertigo, dizziness, abnormal liver function, hepatitis and jaundice, bilirubinuria, urinary frequency, dysuria.

DRUG INTERACTION

* Etodolac may reduce the antihypertensive effect of ACE-inhibitors (Captopril, enalapril). * Coadministration of etodolac with corticosteroids (used to treat inflammation, severe allergic and inflammatory conditions) may increase risk of gastrointestinal ulceration or bleeding * Etodolac may enhance the effects of anti-coagulants (used as blood thinner), such as warfarin * Etodolac should not be used for 8 – 12 days after mifepristone administration as it can reduce the effect of mifepristone * Concomitant use of two or more NSAIDs (including aspirin) as this may increase the risk of adverse effects * Etodolac can increase the risk of fits (convulsions) associated with quinolone antibiotics. * Etodolac can cause reduced production of urine (diuretic effect) and diuretics (water pills) when used with etodolac can increase the risk of harming kidney (nephrotoxicity). * Etodolac may exacerbate cardiac failure, reduce filtration by kidneys (GFR) and increase plasma glycoside levels * Etodolac may decrease the elimination of lithium (used to treat psychiatric disorders) and methotrexate (used to treat certain types of cancer, psoriasis and rheumatoid arthritis) * Concomitant use of etodolac with cyclosporin, tacrolimus may increase risk of nephrotoxity * Increased risk of hematological toxicity when etodolac is given with zidovudine * Concomitant use of etodolac with anti-platelet agents and selective serotonin reuptake inhibitors (SSRIs) may increase risk of gastrointestinal bleeding * Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Etodolac belongs to a class of medicine called non-steroidal anti-inflammatory drugs (NSAIDs). Etodolac exerts a lasting analgesic and an anti-inflammatory effect as it reduces the production of pain stimulating chemicals (prostaglandins) by inhibiting the enzyme cyclooxygenase (COX).

DOSAGE

Always follow the instructions of doctor regarding dosage, duration and frequency of use.Non-steroidal anti-inflammatory drugs (NSAIDS) like etodolac) should be used at the lowest dose possible for your treatment and for shortest time needed.Pain and inflammation in rheumatoid arthritis and osteoarthritisAdult over 18 years:  * 600 mg to 1000 mg daily in 1–2 divided doses.Children:  * Not recommended

DOs and DON'Ts

Etodolac may cause dizziness, drowsiness, fatigue and visual. If affected, patients should not drive or operate machinery.Consult your doctor before you take etodolac  * if you are suffering from kidney, liver or heart failure or high blood pressure of fluid retention * If you are suffering from GI bleeding, ulceration or perforation or with GI conditions such as ulcerative colitis or Crohn’s disease. * If you are suffering from asthma or other breathing difficulties * If you are at a child bearing age and planning to get pregnant or are breast feeding.Tell your doctor or laboratory technician for urine analysis or blood test, if you are taking etodolac, as it may influence the levels of certain urine (urinary bilirubin or ketone bodies) and blood parameters (serum uric acid levels).

CONTRA INDICATIONS

* Patients with a history of hypersensitivity to any NSAID * Patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs * Patients who have experienced gastrointestinal bleeding due to other NSAIDs, perforation or peptic ulcers * Patients suffering from kidney, liver or heart failure * In pregnant women during the third trimester  * Children under 18 years of ahb•NSAIDs (including etodolac) should never be used for pain right before or after a heart bypass surgery.

FAQ

Q. Is etodolac safe?Etodolac is safe if used at prescribed doses for the prescribed duration as advised by your doctor.Q. Is etodolac controlled substance?No, etodolac is not a controlled substance.Q. Is etodolac better than ibuprofen?Etodolac belongs to the same class of medicines like ibuprofen. The effects of both are comparable.Q. Is etodolac like/ same as ibuprofen?Etodolac also belongs to a group of medicines called NSAID like ibuprofen and has the same effect as ibuprofen in treating pain and inflammation.Q. Is etodolac an antibiotic?No, etodolac belongs to a class of medicine called non-steroidal anti-inflammatory drugs (NSAIDs), used to treat pain and inflammation.Q. Can I take etodolac for headache, toothache and back pain?Yes, etodolac can be taken for headache, toothache and back pain. Always follow the instructions of doctor regarding dosage, duration and frequency of use.Q. Can I take etodolac with Aleve (naproxen)/naproxen/meloxicam/Vicodine (acetaminophen and hydrocodone)/Percocet (acetaminophen and oxycodone)/aspirin?Aleve (naproxen)/naproxen/meloxicam/Vicodine (acetaminophen and hydrocodone)/Percocet (acetaminophen and oxycodone)/aspirin are all drugs that belong to the same group of medicines as etodolac i.e. non-steroidal anti-inflammatory drugs (NSAIDs) and therefore, concomitant use of two or more NSAIDs (including aspirin) may increase the risk of adverse effects. Always follow the instructions of doctor regarding dosage, duration and frequency of use, and any concomitant medication used.Q. Can I take etodolac with hydrocodone/ tramadol/oxycodone?Hydrocodone/ tramadol/oxycodone also have pain relief (analgesic) action. Concomitant use with etodolac provides additive pain relief in severely painful conditions like post-surgical pain; however the combination may also increase the risk of adverse effects. Always follow the instructions of doctor regarding dosage, duration and frequency of use, and any concomitant medication used.Q. Can I take etodolac with flexeril?Yes, flexeril is a muscle relaxant. You may be given etodolac with flexeril for painful muscle conditions. Always follow the instructions of doctor regarding dosage, duration and frequency of use, and any concomitant medication used.Q. Can I take etodolac with prednisolone/prednisone?No, prednisone/ prednisolone is a corticosteroid (used to treat inflammation). Coadministration of etodolac with corticosteroids may increase risk of gastrointestinal ulceration or bleeding.Q. Can I take etodolac for headaches?Yes, etodolac is a painkiller and can be used for headaches.Q. Does etodolac make you sleepy/high?Yes, etodolac may make you feel sleepy. It is not known if it makes one feel high. Q. Does etodolac cause constipation and weight gain?Etodolac is not known to cause constipation and weight gainQ. Is etodolac a muscle relaxer?No, etodolac is not known to cause muscle relaxation. Etodolac belongs to a class of medicine called non-steroidal anti-inflammatory drugs (NSAIDs), used to treat pain and inflammation.Q. Does etodolac expire?All etodolac formulations have an expiry date. Read the expiry information on the product package.Q. Does etodolac have aspirin/ acetaminophen?No, etodolac does not have aspirin/ acetaminophen. Etodolac is active molecule similar to aspirin and both belong to same group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). All the three medicines are used to relieve pain. Acetaminophen is also used to bring down the fever.

FURTHER INFORMATION

1. Product Information leaflet:    http://www.google.co.in/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&    ved=0CCMQFjAB&url=http%3A%2F%2Fwww.accessdata.fda.gov%2F    drugsatfda_docs%2Flabel%2F2006%2F018922s022%2C020584s009lbl.    pdf&ei=q-QLVaj_IIicugT9lYGICQ&usg=AFQjCNH5ZQVGcLZsOEkH4t4    zSExa44QDUA&bvm=bv.88528373,d.c2E2. Summary of Product characteristics: http://www.medicines.org.uk/emc/medicine/275323. British National Formulary 61, 20114. http://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf

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INTERACTIONS

Can I take Proxyn (300mg) during pregnancy?

Experiences of drug use and evidence from studies in pregnant women have shown risk to fetus. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Proxyn (300mg) while breastfeeding/lactation?

Contraindicated: The drug should not be used by breastfeeding women, as evidences from studies have shown that there is a high risk of causing significant damage to infants.

Can I take Proxyn (300mg) with alcohol?

No studies found