MRP:Rs. 95 for 1 Strip(s) (10 Tablet each)
Discounted Price:Rs. 95 (0% OFF)
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Composition

Repaglinide(1 mg)

SALT INFORMATION

Repaglinide(1 mg)

TYPICAL USAGE

Type II diabetes mellitus.

SIDE EFFECTS

Headache, Diarrhea, Anaphylactoid reactions, Constipation, Allergy, Nausea and vomiting, Thrombocytopenia, Chest pain, Bronchitis.

DRUG INTERACTION

Repaglinide is metabolized (eliminated) in the liver by an enzyme called CYP3A4. Drugs that affect this enzyme may affect the blood levels of repaglinide and thus alter its glucose lowering effect. The metabolism of repaglinide may be prevented by ketoconazole (Nizoral),itraconazole (Sporanox), fluconazole (Diflucan), erythromycin (Ery-Tab), andclarithromycin (Biaxin). As a result, blood levels of repaglinide rise and there is an enhanced glucose-lowering effect. Dangerous hypoglycemic (very low blood glucose) reactions could occur. On the other hand, the elimination of repaglinide may be increased with drugs that increase levels of CYP3A4 in the liver, such as barbiturates, carbamazepine (Tegretol), and rifampin (Rifadin). This can result in lower blood levels of repaglinide andhyperglycemia (high blood glucose).

MECHANISM OF ACTION

Repaglinide stimulates release of insulin from pancreatic ?-cells by inhibiting K efflux via closure of ATP regulated K channels. This results in depolarization of the cell and opening of voltage-dependent Ca channels, which increases influx of Ca into the beta cells and causes release of insulin.

SUBSTITUTES

11 Substitutes
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RelevancePrice
  • Repa (1mg)
    (10 Tablet in Strip)
    Orchid Chemicals & Pharmaceuticals Ltd
    Rs. 3.90/Tablet
    Tablet
    Rs. 39
    save 59% more per Tablet
  • Page (1mg)
    (10 Tablet in Strip)
    Orchid Chemicals & Pharmaceuticals Ltd(Diabetes)
    Rs. 4.18/Tablet
    Tablet
    Rs. 41.80
    save 56% more per Tablet
  • Rapilin (1mg)
    (10 Tablet in Strip)
    Sun Pharmaceutical Industries Ltd
    Rs. 5.60/Tablet
    Tablet
    Rs. 56
    save 41% more per Tablet
  • Q Repa(1mg)
    (10 Tablet in Strip)
    Q Check Speciality Care
    Rs. 4.70/Tablet
    Tablet
    Rs. 47
    save 51% more per Tablet
  • Repide (1mg)
    (10 Tablet in Strip)
    Wallace Pharmaceuticals Pvt Ltd
    Rs. 4.80/Tablet
    Tablet
    Rs. 48
    save 49% more per Tablet

INTERACTIONS

Can I take Reglide (1mg) during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Reglide (1mg) while breastfeeding/lactation?

Possibly unsafe: Evidence from studies in breastfeeding women show that there is a definite risk of side effects to the breastfed infants. However, use of the drug in breastfeeding women is acceptable in spite of the risk to the infants, if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective. Patients should follow the advice of the doctor regarding its use.

Can I take Reglide (1mg) with alcohol?

Since there is some doubt about the results of concurrent use in this interaction, it is advised to give some guidance to the patient about its possible adverse effects and/or consider close monitoring.