SALT INFORMATIONMeropenem(1000 mg)
Meropenem is used to treat bacterial infections of lung (pneumonia), brain (meningitis), urinary tract, abdomen, blood, skin and soft tissue. It is also used to treat lung and bronchial infections and infections during or after delivery. It may be used in the management of reduced white blood cells (neutropenic) patients with fever.
* Common: Increased blood platelets (thrombocytosis), headache, diarrhea, vomiting, urge to vomit (nausea), abdominal pain, increase in transaminase enzyme, rash, itching of skin (pruritis), inflammation and pain at the site of injection. * Uncommon: Fungal infection in mouth and vagina (oral and vaginal candidiasis), reduced level of blood cells called eosinophils (eosinophilia), or blood platelets (thrombocytopenia), or white blood cells (neutropenia); increased level of bilirubin, creatinine, or urea in blood; inflammation of a vein caused by a blood clot (thrombophlebitis), abnormal sensations (tingling, numbness, pricking, burning) of skin (paresthesia), and pale red, raised, itchy skin rash (urticaria). * Rare: Fits (convulsions).
* Simultaneous administration of meropenem with warfarin may increase its anti-coagulant effect. * Tramadol may increase risk of seizures when combined with meropenem. * The effectiveness of sodium valproate may be decreased by meropenem. * Probenecid increases the blood level of meropenem if taken together and increase their side effects or toxicity. * Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Meropenem belongs to a group of medicines called carbapenem beta-lactam antibiotics. It kills bacteria by inhibiting bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptures, thereby killing the bacteria.
Always follow the instructions of doctor regarding the dosage and duration. * For treatment of bacterial infections: - Adults and adolescents(>50 kg body weight): 500-2000 mg thrice daily - Children (3 months-12 years)(< 50 kg body weight): 10−40 mg for each kg of the child’s body weight thrice dailyNote: Doses are given in powder for solution for intravenous infusion or injection
DOs and DON'Ts
* Meropenem is given as an injection directly into a vein by a doctor or nurse using water for injections or a suitable infusion fluid. * Do not start or continue the meropenem and consult your doctor: - If you have kidney or liver problems - If you have a history of seizures or central nervous system problems (e.g. brain lesions) - If you experience severe and persistent diarrhea after taking antibiotics - If you are taking other drugs like probenecid, valproic acid, or oral anticoagulants like warfarin - If you are pregnant, planning to become pregnant or breastfeeding
Do not take meropenem if you are allergic to it or to other carbapenem or to other beta-lactams antibiotics (penicillins or cephalosporins), or any of the other ingredients of this drug.
Q. Is meropenem a penicillin, cephalosporin, or beta lactam drug?Meropenem is not a penicillin or cephalosporin drug. It is a carbapenem beta-lactam antibiotic.Q. Is meropenem safe during pregnancy?Meropenem should only be given during pregnancy if need has been clearly established. Please consult your doctor before taking the drug.Q. Is meropenem safe?Meropenem is relatively safe if used at prescribed doses for the prescribed duration as advised by your doctor.Q. Is meropenem dialyzable?Yes, meropenem is dialyzable.Q. Is meropenem compatible with vancomycin, or potassium?Meropenem may be compatible with potassium or vancomycin. Please consult your doctor before taking the drug.Q. Is meropenem nephrotoxic, vesicant or cause thrombocytopenia?Meropenem may be nephrotoxic, vesicant, and may cause thrombocytopenia. Please consult your doctor if you experience these side effects.Q. What organisms does meropenem cover?Meropenem is active against gram-positive and gram-negative bacteria, aerobes as well as anaerobes. It is effective against enterococcus, streptococcus, and methicillin-sensitive Staphylococcus aureus (MSSA), but not effective against listeria or methicillin-resistant Staphylococcus aureus.
1. Summary of product characteristics: https://www.medicines.org.uk/emc/medicine/241502. Patient information leaflet: https://www.medicines.org.uk/emc/PIL.24137.latest.pdf3. Drugs.com: http://www.drugs.com/monograph/meropenem.html
- Synmero (1000mg)(1 Powder for Injection in Vial)Sanify Healthcare Pvt LtdRs. 139.90/Powder for InjectionRs. 139.90save 87% more per Powder for Injection
- Mexico (1000mg)(1 Powder for Injection in Vial)Reco Drugs Pharmaceuticals LtdRs. 750/Powder for InjectionRs. 750save 31% more per Powder for Injection
- Meromac (1000mg)(1 Powder for Injection in Vial)Macleods Pharmaceuticals LtdRs. 871/Powder for InjectionRs. 871save 20% more per Powder for Injection
- Zaxter Kit(1gm)(1 Powder for Injection in Vial)Alkem Laboratories LtdRs. 899/Powder for InjectionRs. 899save 17% more per Powder for Injection
- Penmax (1000mg)(1 Powder for Injection in Vial)Ace Kinetics Health Care Pvt LtdRs. 990/Powder for InjectionRs. 990save 9% more per Powder for Injection
Can I take Ronem (1000mg) during pregnancy?
Studies in animals have shown no risk to the fetus, however there are no sufficient studies in humans. Patients should follow the advice of the doctor regarding its use. Patients should follow the advice of the doctor regarding its use.