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Composition

Piroxicam(20 mg)

SALT INFORMATION

Piroxicam(20 mg)

TYPICAL USAGE

Piroxicam is used to relieve swelling, stiffness and joint pain in various diseases of the joints like osteoarthritis and rheumatoid arthritis

SIDE EFFECTS

* Common: changes in the red blood cells which may result in unusual bruising or bleeding, changes in the white blood cells which may result in increased risk of infection, anorexia, increase in blood sugar levels, dizziness, headache, spinning sensation (vertigo), drowsiness, ringing in ears (tinnitus), abdominal pain/discomfort, constipation, diarrhea, wind, urge to vomit (nausea),vomiting, indigestion, itching, skin rash, swelling of the feet, hands or other parts of the body (edema), weight increase * Uncommon: blurred vision, fast or pounding heartbeat, sore mouth and/or lips, decreased/low blood sugar level * Rare: kidney inflammation, kidney failure, kidney damage, change in urine output or appearance, kidney pain or pain in abdomen * Very rare: Stevens-Johnson syndrome (potentially life-threatening skin rashes including peeling skin, particularly around the mouth, nose, eyes and genitals) or extensive peeling of the skin (toxic epidermal necrolysis)  * When applied in gel form on the affected area it may cause side effects like: redness, rash and/or itching of the skin, reaction of the skin to the sunlight

DRUG INTERACTION

* The following medicines must not be taken with Piroxicam:                 -aspirin or other non-steroidal anti-inflammatory drugs for pain relief                 -anticoagulants such as warfarin to prevent blood clots * Avoid concomitant and systemic use of indomethacin with the following:                 -corticosteroids, low dose aspirin, digoxin, certain medicines for depression such as                     lithium or selective serotonin re-uptake inhibitors (SSRIs), antihypertensives,                               methotrexate, ciclosporin or tacrolimus, quinolone antibiotics e.g.ciprofloxacin,                           mifepristone, diuretics such as hydrochlorothiazide  * Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required

MECHANISM OF ACTION

Piroxicam is one of a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by decreasing the production of a chemical (prostaglandins) that cause inflammation and pain in the body.

DOSAGE

Always follow the instructions of doctor regarding the dosage and duration  * The recommended adult oral dose for osteoarthritis, pain, rheumatoid arthritis in adults is 20 mg: 20 mg orally once a day or 10 mg orally twice a day * The recommended pediatric dose for pain is 15mg: 0.2 to 0.3 mg/kg orally once a day * Piroxicam gel for adults and children: For external use only. No occlusive dressings should be employed. Apply 1g of Gel, corresponding to 3cm, and rub into the affected site three to four times daily leaving no residual material on the skin. Therapy should be reviewed after 4 weeks * Piroxicam gel is not recommended for use in children under 12 years of age

DOs and DON'Ts

* Piroxicam should always be taken with or after food  * Before you take Piroxicam, tell your doctor:                         -if you have liver disease                          -if you have kidney disease                          -if you have high blood pressure, heart problems or stroke                          -if you have high cholesterol or hardening of the arteries                          -if you have asthma                          -if you have diabetes                          -if you have polyps in your nose                          -If you have previously had or currently have a stomach or intestinal ulcer,                                  bleeding or perforation.                           -If you have, or have previously had disorders of the stomach or intestines                                  such as ulcerative colitis, Crohn’s disease, gastrointestinal cancers or                                          diverticulitis (inflamed or infected pouches/pockets in the colon).                           -If you are taking other NSAIDs such as ibuprofen, celecoxib or acetylsalicylic                              acid (aspirin), a substance present in many medicines used to relieve pain                                  and lower fever.                            -If you are taking anticoagulants, such as warfarin, to prevent blood clotsif you                             are planning to become pregnant or if you have problems becoming                                           pregnant, piroxicam may make it more difficult to become pregnant                          -If while taking piroxicam, you develop any allergic reaction such as a skin                                    rash, swelling of the face, wheezing or difficulty breathing, serious reactions in                            the stomach and intestines, such as pain, bleeding, ulceration and perforation * Do not exceed the recommended dose or duration of treatment. You might be at small increased risk of heart attack (‘myocardial infarction’) or stroke * Piroxicam can cause fatigue, dizziness, drowsiness and visual disturbances in some people. If this happens to you, avoid activities which require you to be alert; for example, driving a car and operating machinery * Avoid prolonged exposure to sunlight. Piroxicam may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable

CONTRA INDICATIONS

Do not take piroxicam if you: * Previously had or currently have a stomach or intestinal ulcer, bleeding or perforation. * If you have, or have previously had disorders of the stomach or intestines such as ulcerative colitis, Crohn’s disease, gastrointestinal cancers or diverticulitis (inflamed or infected pouches/pockets in the colon) * If you are taking other NSAIDs such as ibuprofen, celecoxib or acetylsalicylic acid (aspirin), a substance present in many medicines used to relieve pain and lower fever * If you are taking anticoagulants, such as warfarin, to prevent blood clots * If you previously had an allergic reaction (especially serious skin reactions to piroxicam, (the active ingredient in this medicine) or any of the other ingredients, other NSAIDs or any other medications) * If you have severe heart failure * If you are in the last three months of pregnancy

FAQ

Q.Is piroxicam/ Dolonex/ Dolonex DT a pain killer?Dolonex and Dolonex DT are brand names of piroxicam. Piroxicam is used to relieve pain and reduce swelling affecting joints.Q.Is piroxicam a narcotic/ opiate/ a cox 2 inhibitor/acidic or basic/ a controlled substance/ addictive?No, piroxicam is non-narcotic and not an opiate. It is a non- selective cox inhibitor and slightly acidic. It is not a controlled substance and it can be an addictive drug for some people, and this is why you should ensure regularly check up with your doctor.Q.Is piroxicam a blood thinner?Piroxicam is not a blood thinner, but it may enhance the effect of anticoagulants (blood thinners).Q.Is piroxicam safe in pregnancy?Piroxicam is not recommended for use in pregnant women since its safety has not been established.Q.Is piroxicam the same as ibuprofen?Piroxicam and ibuprofen, both are non-steroidal anti-inflammatory drugs (NSAID). They are similar in action but are not identical drugs. Ibuprofen is milder and is used to relieve pain, inflammation, fever due to many conditions such as migraine, headache, dental pain, arthritis, etc. Piroxicam, on the other hand, is generally used to relieve pain and reduce swelling affecting joints.Q.Can I take piroxicam with Ibuprofen/Tylenol/Advil/ paracetamol/ Tramadol/ Acetaminophen/ naproxen?It can be taken with ibuprofen, paracetamol, naproxen, tramadol, Tynelol, Advil.Q.Does piroxicam causes weight gain/ high/strink tumors/constipation/ sleepy?It may cause these side effects, but you should consult your doctor.Q.Does piroxicam contain aspirin/ acetaminophen/ibuprofen?No it does not contain aspirin/acetaminophen/ibuprofen.

FURTHER INFORMATION

1.Prescribing information. https://www.medicines.org.uk/emc/PIL.3099.latest.pdf 2.Summary of product characteristics: https://www.medicines.org.uk/emc/medicine/27267# 3.Prescribing information. https://www.medicines.org.uk/emc/medicine/1462 4.Summary of product characteristics: https://www.medicines.org.uk/emc/PIL.5584.latest.pdfhttp://www.drugs.com/mtm/piroxicam.html 

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INTERACTIONS

Can I take Roxidin Dt(20mg) during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Roxidin Dt(20mg) while breastfeeding/lactation?

Contraindicated: The drug should not be used by breastfeeding women, as evidences from studies have shown that there is a high risk of causing significant damage to infants.

Can I take Roxidin Dt(20mg) with alcohol?

No studies found