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Composition

Rifaximin(400 mg)

SALT INFORMATION

Rifaximin(400 mg)

TYPICAL USAGE

Rifaximin is an antibiotic used to treat bacterial infections of the intestine( traveller's  diarrhea). Rifaximin is also used to lower the risk of worsened brain function in adults with liver failure. Brain function can be affected when the liver stops working and cannot remove toxic substances from the body.

SIDE EFFECTS

* Common: Stomach ache or bloating/swelling, urge to vomit, vomit,  diarrhea (Clostridium difficile associated diarrhea (CDAD)), accumulation of fluid in the abdominal cavity dizziness, depressed mood, headache, shortness of breath, muscle cramps, joint pain, swelling of ankles, feet or fingers, rash or itching * Uncommon: feeling unsteady, loss of or poor memory, loss of concentration, confusion, anxiety, feeling sleepy, difficulty sleeping, dry mouth, hot flushes, yeast infections (such as thrush), urinary infection (such as cystitis), anemia, loss of appetite, high level of potassium in the blood (hyperkalemia), needing to pass urine more often than usual, difficulty or pain passing urine, convulsions (fits), fever, reduced sense of touch, falls, fluid around the lungs, swelling due to too much fluid in the body (edema), muscle pain * Rare: bruising, protein in urine, chest infections including pneumonia, cellulitis, upper respiratory tract infection, constant breathing problem such as bronchitis, inflammation inside the nose (rhinitis), body water loss (dehydration), change in blood pressure, feeling weak, constipation, back pain * Frequency not known: fainting, skin irritation, red itchy dry skin (eczema), change in liver and blood coagulation based on blood test.

DRUG INTERACTION

Caution should be taken if you are taking any of the following medicines: * antibiotics * warfarin * antiepileptics * antiarrhythmics * bosutinib * eliglustat * ibrutinib * ledipasvir / sofosbuvirAlways consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required

MECHANISM OF ACTION

Rifaximin is a broad spectrum antibacterial drug that fights bacterial infection only in the intestines. Rifaximin stops the growth of bacteria that produce toxins and that may worsen liver disease.

DOSAGE

Always follow the instructions of doctor regarding the dosage and duration. * The recommended adult oral dose for hepatic and renal impairment is 550 mg twice a day. * Rifaximin is not recommended for use in children under 18 years of age. * For treatment of traveller’s diarrhea, the recommended adult dose and children over 12 years of age is 200 mg orally 3 times a day for 3 days.

DOs and DON'Ts

While you are taking rifaximin, it may cause a reddish discolouration of the urine. This is quite normal.If you are using oral contraceptives take additional precautions while taking rifaximin. Oral contraceptives may not work as well when you are taking this medicine and/or when you have diarrhea.Rifaximin does not normally affect the ability to drive and use machines, but may cause dizziness in some patients. If you feel dizzy you should not drive or operate machinery.if you are pregnant or breast feeding speak to your doctor before starting the drug.To make sure rifaximin is safe for you, tell your doctor if you have: * liver disease * diarrhea with a fever * watery or bloody diarrheaTreatment with any antibiotic including rifaximin may cause severe diarrhea. You should stop taking it and contact your doctor immediately. Diarrhea may even occur few months after the drug has been stopped.

CONTRA INDICATIONS

* Do not take rifaximin with other rifamycins due to the potential for severe disruption of gut flora with unknown consequences * Do not take rifamixin if you have hypersensitivity to rifaximin or any rifamycin-derivatives  * Do not take rifamixin if you previously had a case history of intestinal obstruction

FAQ

Q. Is rifaximin an antibiotic/ is rifaximin FDA approved for irritable bowel syndrome (IBS)/help in IBS?Yes, rifaximin (also available as Rifagut) is an antibiotic. It is not yet approved by the FDA for the treatment of IBS.Q. Is rifaximin safe/ safe in pregnancy?Rifaximin is safe if used at prescribed doses for the prescribed duration as advised by your doctor. Its safety in pregnant women has not been established. Patients should follow the advice of the doctor regarding its use.Q. Is rifaximin available over the counter/ is it available in UK/ Canada/ Australia?No, it is available only with your doctor's prescription. It is available in UK, Canada, Australia.Q. Is rifaximin the same as rifampin?Rifaximin is a structural analog of rifampin.Q. Is rifagut an antibiotic?Rifagut is a brand name for rifaximin. Yes, it is an antibiotic. Q. Can I take xifaxan with amoxicillin/ibuprofen?Xifaxan is the brand name for rifaximin and can be taken with ibuprofen, but not with amoxicillin, as it is antibiotic. If taken with other antibiotics, rifaximin causes diarrheaQ. Does rifaximin cause diarrhea/gas/constipation?It may rarely cause these side effects. Q. Does rifaximin kill parasites/yeast?It is antibiotic and doesn’t kill parasites and yeast.

FURTHER INFORMATION

* Prescribing information. http://www.medicines.org.uk/emc/medicine/28104  * Summary of product characteristics: http://www.medicines.org.uk/emc/medicine/27427 * http://www.drugs.com/mtm/rifaximin.html 

SUBSTITUTES

7 Substitutes
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  • Rixmin (400mg)
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    Cipla Ltd
    Rs. 20.55/Tablet
    Tablet
    Rs. 205.50
    save 13% more per Tablet
  • Rifagut (400mg)
    (10 Tablet in Strip)
    Sun Pharmaceutical Industries Ltd
    Rs. 22.50/Tablet
    Tablet
    Rs. 225
    save 4% more per Tablet
  • Rcifax (400mg)
    (10 Tablet in Strip)
    Lupin Laboratories Ltd
    Rs. 23.50/Tablet
    Tablet
    Rs. 235
    same price
  • Rifaximax (400tab 10)
    (10 Tablet in Strip)
    Emcure Pharmaceuticals Ltd
    Rs. 21.58/Tablet
    Tablet
    Rs. 215.80
    save 8% more per Tablet
  • Zimigut (400tab 10)
    (10 Tablet in Strip)
    Intas Pharmaceuticals Ltd
    Rs. 23.20/Tablet
    Tablet
    Rs. 232
    save 1% more per Tablet

INTERACTIONS

Can I take Sibofix (400mg) during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Sibofix (400mg) while breastfeeding/lactation?

Possibly unsafe: Evidence from studies in breastfeeding women show that there is a definite risk of side effects to the breastfed infants. However, use of the drug in breastfeeding women is acceptable in spite of the risk to the infants, if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective. Patients should follow the advice of the doctor regarding its use.

Can I take Sibofix (400mg) with alcohol?

No studies found