Glimepiride is used to lower the blood sugar levels in type 2 diabetes mellitus.
The common side effects are excessively low blood sugar levels, abnormal increase in liver enzymes, jaundice, problems with the bile flow, inflammation of the liver, liver failure. You should consult your doctor immediately if you experience allergic reactions such as skin rash, itching, hives and increased sensitivity to sun, difficulty in breathing, fall in blood pressure, shock, loss of consciousness, seizures or comma.
Drugs that affect the action of glimepiride by altering blood sugar level include hydrochlorothiazide, furosemide, prednisone, methylprednisolone, phenytoin, niacin, pseudoephedrine, propranolol, and atenolol. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Glimepiride increases the amount of insulin released by the pancreas, and thereby decreases the blood sugar level.
Metformin is used in the treatment of diabetes mellitus, insulin resistance, and obesity.
The common side effects are urge to vomit, vomiting, diarrhea, abdominal pain, loss of appetite, malabsorption of vitamin B12, taste disturbance, and altered liver functions. Also, the patient may have the side effects of lactic acidosis (symptoms are vomiting, abdominal pain with muscle cramps, not feeling well with severe tiredness, and difficulty in breathing), and skin reactions such as redness of skin, itching, hives (pale red, raised, itchy bumps of skin).
Taking metformin with other anti-diabetic drugs may lead to excessive lowering of bloodsugar. If you go for an X-ray or scan, do not take metformin before and at least 48 hours afterwards. Metformin with diuretics (furosemide), anti-asthmatic drugs such as salbutamol or terbutaline, or corticosteroids (prednisone) may affect the glucose control. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
The exact mechanism of action of metformin is not clear but it appears to act by decreasing glucose absorption from the intestine, decreasing production of glucose from proteins and fats in liver, and enhancing insulin sensitivity in muscle by increasing glucose uptake and utilization.
To control high blood glucose in type 2 diabetes mellitus
Jaundice, headache, muscle pain, sore throat (pharyngitis), inflammation of the sinus (sinusitis), reduced sense of touch or sensation (hypesthesia), eyesight problems, weight gain and bone fracture.
Drugs that are likely to affect the effect of pioglitazone are gemfibrozil, rifampicin, beta blockers, gatifloxacin, teriflunomide, leflunomide, lomitapide and mipomersen. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required
MECHANISM OF ACTION
Pioglitazone often referred to as an "insulin sensitizer" because it acts on cells throughout the body and causes the cell to become more sensitive (more responsive) to insulin. As a result, more glucose is taken into the cells (absorbed) from the blood, and the level of glucose in the blood reduces. Pioglitazone also lowers the level of glucose in the blood by reducing the production of glucose by the liver. It also decreases triglycerides and increases the "good" (HDL) cholesterol.
- Endoformin Pg(10 Tablet in Strip)Precia PharmaRs. 1.07/TabletRs. 10.70save 73% more per Tablet
- Tri Piomed 2(10 Tablet in Strip)Ipca Laboratories LtdRs. 4.48/TabletRs. 44.80pay 12% more per Tablet
- Trimetaday (2mg)(10 Tablet in Strip)Wockhardt LtdRs. 5/TabletRs. 50pay 25% more per Tablet
- Tri Azulix 2tab(10s)(10 Tablet in Strip)Torrent Pharmaceuticals LtdRs. 7.80/TabletRs. 78pay 95% more per Tablet
- Adglim Mp(2mg)(10 Tablet in Strip)CadellRs. 4.50/TabletRs. 45pay 12% more per Tablet
Can I take Triexer Ls(2) during pregnancy?
The drug should not be used by pregnant women. Experiences of drug use and evidence from studies in pregnant women have shown high risk to fetus. The risk of drug use in pregnant women outweighs the benefit.
Can I take Triexer Ls(2) while breastfeeding/lactation?
Can I take Triexer Ls(2) with alcohol?
Since there is some doubt about the results of concurrent use in this interaction, it is advised to give some guidance to the patient about its possible adverse effects and/or consider close monitoring.