Glimepiride is used to lower the blood sugar levels in type 2 diabetes mellitus.
The common side effects are excessively low blood sugar levels, abnormal increase in liver enzymes, jaundice, problems with the bile flow, inflammation of the liver, liver failure. You should consult your doctor immediately if you experience allergic reactions such as skin rash, itching, hives and increased sensitivity to sun, difficulty in breathing, fall in blood pressure, shock, loss of consciousness, seizures or comma.
Drugs that affect the action of glimepiride by altering blood sugar level include hydrochlorothiazide, furosemide, prednisone, methylprednisolone, phenytoin, niacin, pseudoephedrine, propranolol, and atenolol. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Glimepiride increases the amount of insulin released by the pancreas, and thereby decreases the blood sugar level.
It is used in the treatment of patient's with type 2 diabetes (non-insulin dependent diabetes). Metformin controls high level of sugar in the blood therefore prevents kidney damage, blindness and peripheral nerve problem.
The common side effects are urge to vomit, vomiting, diarrhea, abdominal pain, loss of appetite, malabsorption of vitamin B12, taste disturbance, and altered liver functions. Also, the patient may have the side effects of lactic acidosis (symptoms are vomiting, abdominal pain with muscle cramps, not feeling well with severe tiredness, and difficulty in breathing), and skin reactions such as redness of skin, itching, hives (pale red, raised, itchy bumps of skin).
Taking metformin with other anti-diabetic drugs may lead to excessive lowering of bloodsugar. If you go for an X-ray or scan, do not take metformin before and at least 48 hours afterwards. Metformin with diuretics (furosemide), anti-asthmatic drugs such as salbutamol or terbutaline, or corticosteroids (prednisone) may affect the glucose control. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Metformin decrease the level of glucose in the body by 1. Delays glucose absorption. 2. Decreases hepatic and renal glucose output. 3. Increases the peripheral glucose utilisation by enhancing anaerobic glycolysis (Breaking of sugar in the body). 4. Increasing the sensitivity of liver, muscle, fat, and other tissues to the uptake and effects of insulin.
To control high blood glucose in type 2 diabetes mellitus
Jaundice, headache, muscle pain, sore throat (pharyngitis), inflammation of the sinus (sinusitis), reduced sense of touch or sensation (hypesthesia), eyesight problems, weight gain and bone fracture.
Drugs that are likely to affect the effect of pioglitazone are gemfibrozil, rifampicin, beta blockers, gatifloxacin, teriflunomide, leflunomide, lomitapide and mipomersen. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required
MECHANISM OF ACTION
Pioglitazone often referred to as an "insulin sensitizer" because it acts on cells throughout the body and causes the cell to become more sensitive (more responsive) to insulin. As a result, more glucose is taken into the cells (absorbed) from the blood, and the level of glucose in the blood reduces. Pioglitazone also lowers the level of glucose in the blood by reducing the production of glucose by the liver. It also decreases triglycerides and increases the "good" (HDL) cholesterol.
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Can I take Tripride during pregnancy?
The drug should not be used by pregnant women. Experiences of drug use and evidence from studies in pregnant women have shown high risk to fetus. The risk of drug use in pregnant women outweighs the benefit.
Can I take Tripride while breastfeeding/lactation?
Can I take Tripride with alcohol?
Since there is some doubt about the results of concurrent use in this interaction, it is advised to give some guidance to the patient about its possible adverse effects and/or consider close monitoring.